Aza-BODIPY荧光染料的合成、表征及性能研究  

Synthesis,Characterization and Properties of Aza-BODIPY Fluorescent Dyes

作　　者：李翠红[1] 沈田华[1] 陈小利[1] 周彩琪[1] 张诚[1] 宋庆宝[1] 

机构地区：[1]浙江工业大学化学工程与材料学院,杭州310032

出　　处：《有机化学》2011年第9期1440-1444,共5页Chinese Journal of Organic Chemistry

基　　金：国家重点基础研究发展计划(973计划)前期专项基金(No.2010CB635108)资助项目

摘　　要：aza-BODIPY荧光染料是近10年发展起来并受到广泛关注的一类新型荧光化合物,它极有可能发展成可应用于光动力学治疗的光敏剂.本工作合成了5个aza-BODIPY 1a～1e,用IR,NMR,MS和元素分析对它们进行了表征.研究了它们的紫外吸收光谱与荧光发射光谱,结果表明1a～1e具有较高的摩尔吸光系数,在aza-BODIPY母环的3,5位或1,7位的苯环4位有供电子取代基时能使化合物的最大紫外吸收波长和荧光发射波长红移.测试了1a～1d的循环伏安曲线,根据各化合物的氧化还原电位讨论了它们的结构稳定性.A relatively new kind of aza-BODIPY fluorescent compound has been developed and aroused wide attention in the last decade.They are potentially useful photosensitizer for photodynamic therapy.In this work,five aza-BODIPY fluorescent dyes 1a～1e have been synthesized.All the compounds have been identified by IR,NMR,MS techniques and elemental analysis.Their spectra of UV absorption and fluores-cence emission have been also measured.A conclusion can be drawn that aza-BODIPY fluorescent dyes 1a～1e have high molar extinction coefficient,their maximum UV absorption wavelength and fluorescence emission wavelength would red-shift when the electron-donating group onto the para-position of the aryl rings locating 3,5 or 1,7 positions in the aza-BODIPY core.At the same time,cyclic voltammograms of 1a～1d had been scanned,and their structural stability was discussed by oxidation potential of CV.

关 键 词：aza-BODIPY 荧光染料 紫外吸收光谱 荧光发射光谱 循环伏安 

分 类 号：TQ617.3[化学工程—精细化工]