苯甘氨酰胺结晶诱导的动态动力学拆分  

Crystallization-Induced Dynamic Kinetic Resolution of Phenylglycine Amide

作　　者：廖本仁[1,2] 安国成 竹俊如[1] 杨帆[1] 汤杰[1] 

机构地区：[1]华东师范大学化学系,上海200062 [2]上海华谊集团技术研究院,上海200241

出　　处：《有机化学》2011年第9期1495-1498,共4页Chinese Journal of Organic Chemistry

摘　　要：以取代水杨醛为消旋催化剂,通过加入手性助剂,实现了苯甘氨酰胺结晶诱导的动态动力学拆分.在优化条件下,单程收率达82%以上,光学纯度达99%ee.手性助剂可以回收,含消旋催化剂的母液可以循环套用,三次套用的平均收率高达99%,光学纯度>99%ee.With substituted salicylaldehyde as racemization catalyst,crystallization-induced dynamic kinetic resolution of phenylglycine amide was successfully carried out in the presence of resolving agent.Under optimized conditions,the single-run resolution yield was upward 82% with enantiomeric excess higher than 99%.The resolving agent can be recycled,and the mother liquid which contains the racemization catalyst can be reused.The average yield of the three time＇s recycling was up to 99% with ee99%.

关 键 词：苯甘氨酰胺 动态动力学拆分 5-硝基水杨醛 扁桃酸 

分 类 号：O625.525[理学—有机化学]