高脂血症与肝病  

Hyperlipidemia and liver diseases

作　　者：韩英[1] 韩者艺[1] 

机构地区：[1]第四军医大学西京医院消化病医院肝病科,西安710032

出　　处：《中国实用内科杂志》2011年第9期668-670,共3页Chinese Journal of Practical Internal Medicine

摘　　要：肝脏是内源性血脂和脂蛋白合成及代谢的主要器官,高脂血症是非酒精性脂肪肝的高危因素。一方面可因血脂增高,造成肝细胞合成甘油三酯增加及在肝细胞内堆积,从而引起肝脂肪变;另一方面,肝病患者也可因肝脏脂质代谢障碍发生高脂血症。二者可能存在互为因果的恶性循环关系。目前,应重视肝病患者高脂血症及其相关并发症的监测和早期预防,通过改变生活方式或进一步辅助使用降糖、降脂、抗炎、抗氧化等药物,减少高脂血症及并发症和肝硬化的发生。Liver is the major organ for endogenous synthesis and metabolism of lipids and lipoproteins. Hy- perlipidemia is one of high risk factors for non-alcoholic fatty liver disease （NAFLD）. On one hand, elevated level of lipids may lead to an increase in blood triglyceride （TG） and accumulation of TG in hepatocytes, which in turn contributes to fatty change of the liver. On the other hand,hyperlipidemia （hypertriglyceridemia in particular） may occur secondary to liver disorders as a resuhe of impaired metabolism of very low density lipid （VLDL）. A vicious cycle of cause and effect between these two aspects may exist. At present, emphasis should be placed on detection and early prevention of hyperlipidemia and related complications. Life-style modification and use of adjuvant medi- cations such as glucose-lowering, lipid-lowering, anti-inflammatory and anti-oxidative agents may help reducing the development of hyperlipidemia, hyperlipidemia-related complications and liver cirrhosis.

关 键 词：高脂血症 肝脏脂肪代谢 非酒精性脂肪肝 

分 类 号：R589.2[医药卫生—内分泌]