生物降解材料氯代聚乙醇酸甲酯的合成与表征  

Synthesis and Characterization of Biodegradable Methyl Polychloroglycolic Acetate

作　　者：常军[1] 王佳霁 李成吾[1] 左继成[1] 

机构地区：[1]沈阳理工大学材料科学与工程学院,辽宁沈阳110159 [2]北京天坛生物制品股份有限公司,北京110022

出　　处：《化学与粘合》2011年第5期9-13,共5页Chemistry and Adhesion

基　　金：辽宁省教育厅资助项目(编号:L2010472)

摘　　要：以氯乙酸为原料通过溶液缩聚合成了氯代聚乙醇酸(PCA),再与一氯甲烷反应制得氯代聚乙醇酸甲酯(MPCA)。考察了催化剂用量、反应温度和反应时间对PCA和MPCA熔点的影响。在反应时间为4h,反应温度为80℃,氯乙酸与三乙胺的物质的量比为0.9的条件下,PCA和MPCA的熔点分别为210℃和203℃。分别采用傅立叶红外光谱(FT-IR)、X射线衍射仪(XRD)和差示扫描量热仪(DSC)研究了PCA和MPCA的结构、结晶性质和热性能。体外降解实验表明,由于甲基的封端作用,PCA和MPCA在PBS中7d的失重率分别为89.5%和68.6%。MPCA的降解速度有所降低,从而提高了稳定性。With using chloroacetic acid as the raw material, the polychloroglycolic acid （PCA） was synthesized by solution polycondensation. Further more, the methyl polychloroglycolic acetate （MPCA） was synthesized by the reaction between PCA and chloromethane. The effects of catalyst amount, reaction temperature and reaction time on the melting point of PCA and MPCA were investigated. The results showed that the melting points of PCA and MPCA would be 210℃ and 203℃ respectively when the reaction time was 4h, reaction temperature was 80℃ and the molar ratio of chloroacetic acid to triethylamine was 0.9. The FT-IR, XRD and DSC methods were used to study the structure, crystallinity and thermal properties of the PCA and MPCA. The degradation experiment in vitro showed that the weight loss rates of PCA and MPCA in PBS for 7 days were 89.5% and 68.6% respectively because of methyl terminal. And a slower degradation speed of MPCA was obtained which enhanced the stability.

关 键 词：氯乙酸 氯代聚乙醇酸 氯代聚乙醇酸甲酯 生物降解聚合物 溶液缩聚 

分 类 号：TQ322.97[化学工程—合成树脂塑料工业]