基于单向灌流法的艾片大鼠在体鼻黏膜吸收研究  

Study on rat nasal absorption in situ of borneol based on single pass perfusion method

作　　者：宋逍[1,2] 杜守颖[1] 陆洋[1] 马勇[1] 陈晓兰[1] 王玥[1] 张慧贤[1] 

机构地区：[1]北京中医药大学中药学院,北京100102 [2]陕西中医学院药学院,西安陕西712046

出　　处：《中国中药杂志》2011年第18期2489-2492,共4页China Journal of Chinese Materia Medica

基　　金：国家"重大新药创制"科技重大专项(2009ZX09502-008;2009ZX09308-003);国家自然科学基金面上项目(81073057);教育部博士点基金项目(20090013110007)

摘　　要：目的:研究艾片的大鼠在体鼻黏膜吸收影响因素。方法:运用单向灌流模型、采用GC对艾片中有效成分龙脑进行检测,分别研究药物质量浓度、灌流速度、pH对艾片吸收的影响。结果:灌流速度对艾片的吸收速率常数(Ka)有显著性影响;药物质量浓度和pH对Ka无显著性影响。结论:艾片的鼻黏膜吸收良好,艾片的吸收速率不受药物质量浓度的影响,其在鼻腔按照一级被动方程进行吸收。Objective： To investigate the absorption characteristic of borneol.Method： Using single pass perfusion model,the active ingredient of borneol were detected by GC.The drug concentration,perfusion rate and pH value on the absorption of borneol were studied.Result： Perfusion rate on the absorption rate constants（Ka） had significant effects.Drug concentration and pH value on the absorption rate constants had no significant impact.Conclusion： the absorption of borneol is good by nasal.The absorption rate constants of borneol have no effected by drug concentration.The absorption of borneol is via a simple diffusion.

关 键 词：在体鼻吸收 艾片 鼻单向灌流法 

分 类 号：R285[医药卫生—中药学]