海洋红树林微生物土曲霉的代谢产物研究  

Studies on metabolites from marine microorganism Aspergillus terreus collected from nature reserve region of mangrove

作　　者：申毅[1] 邹建华[1] 戴均贵[1] 

机构地区：[1]中国医学科学院&北京协和医学院药物研究所,卫生部天然药物生物合成重点实验室&中草药物质基础与资源利用教育部重点实验室,北京100050

出　　处：《中国中药杂志》2011年第18期2515-2519,共5页China Journal of Chinese Materia Medica

基　　金：“十一五”科技部国家“新药创制重大”专项(2009ZX09301-003-4-1);国家自然科学基金项目(20602042);药物研究所基本科研业务费专项(2007CHX08)

摘　　要：目的:从海洋红树林微生物的代谢产物中寻找抗肿瘤活性化合物。方法:用人工海水培养基培养海洋红树林微生物土曲霉,对其代谢产物进行提取分离,应用现代波谱学分析方法鉴定化合物。结果:从海洋红树林微生物土曲霉的代谢产物中分离得到12个单体化合物。结论:化合物1～4为甾体类化合物,5～8为有机酸和酯类,9为生物碱,10为香豆素类,11为神经酰胺类,12为丙烯基环戊二醇。Objective： To search for new antitumor active lead compounds from marine microorganism.Method： A marine strain,Aspergillus terreus,was cultured and up-scaled in artificial seawater media,from which the metabolites were isolated and elucidated by using modern spectroscopy techniques.Result： Twelve compounds were isolated from mycelia and fermentation broth of A.terreus.Conclusion： Compounds 1-4 were steroids,compounds 5-8 were organic acids and esters,compound 9 was an alkaloid,compound 10 was an isocoumarin,compound 11 was ceramide,compound 12 was propenyl cyclic pentanediol.

关 键 词：海洋微生物 土曲霉 代谢产物 

分 类 号：R284[医药卫生—中药学]