辛伐他汀对糖尿病大鼠大血管病变的干预作用及机制研究  

Intervention effect of simvastatin on vasculopathy in diabetic rats and its mechanism

作　　者：靳瑾[1] 李旭芳[1] 孙侃[2] 王敏哲[1] 

机构地区：[1]新疆医科大学第五附属医院内分泌科,新疆乌鲁木齐830011 [2]石河子大学医学院第一附属医院内分泌科,新疆石河子832002

出　　处：《现代医药卫生》2011年第17期2561-2563,共3页Journal of Modern Medicine & Health

摘　　要：目的:观察辛伐他汀对糖尿病大血管病变大鼠细胞间黏附分子水平(ICAM-1)的影响,以了解其对糖尿病大血管病变的的干预作用。方法:复制糖尿病合并大血管病变大鼠模型,随机分为正常对照组(A组)、正常干预组(B组)、糖尿病对照组(C组)、糖尿病干预组(D组),B组和D组给予辛伐他汀灌胃,A组和C组灌予相应量的生理盐水,8周末检测生化指标、肾周脂肪及血清sICAM-1,留取主动脉观察病理变化。结果:血糖C组和D组相近,均显著高于A组和B组(P<0.01);总胆固醇(TC)、甘油三酯(TG)及低密度脂蛋白(LDL-C)A组高于B组,D组低于C组;C组ICAM-1显著高于A组、B组和D组(P<0.01),D组明显低于C组(P<0.01);光镜下观察胸主动脉病变D组较C组减轻。结论:辛伐他汀干预治疗能够降低TC、TG、LDL-C及ICAM-1的水平,并明显减轻或延缓其大血管病变的发生发展。Objective：To observe the effects of simvastatin on intercellular adhesion molecule-1（ICAM-1） levels in diabetic macroangiopathy rats and to find its possible protective effects on macroangiopathy.Methods：Duplicating rat model of diabetes complicating macroangiopathy,rats were randomly assigned to normal controlgroup（group A）,normal intervention group（group B）,diabetic control group（group C） and diabetic intervention group（group D）.Simvastatin was given to the group B and D by gavage,while the group A and B were gavaged with corresponding normal saline.At the end of 8 weeks,the biochemical indexes,perirenal fat and serum ICAM-1 were detected and the thoracic aorta was taken for observing the pathological change.Results：The blood glucose levels in group C and D was similar,which was significantly higher than that in the group A and B（P0.01）;total cholesterol,triglyceride and low density lipoprotein in group A were much higher than those in the group B,the group D was lower than the group C;ICAM-1 in the group C was much higher than that in the group A,B and D（P0.01）,the group D was much lower than the group C（P0.01）;the pathological changes of aorta thoracalis by light microscope showed that the group D was milder than the group C.Conclusion：Simvastatin intervention treatment can decrease TC,TG,LDL-C and ICAM-1 level and obviously alleviate or delay the occurrence and development of macroangiopathy.

关 键 词：糖尿病 细胞间黏附分子-1 大血管病变 辛伐他汀 

分 类 号：R332[医药卫生—人体生理学]