HLA-G+调节性T细胞在胎膜早破患者的表达差异  

The expression differences of HLA-G + regulatory T cells in patients with premature rupture of membranes.

作　　者：万丽娟[1] 崔丽娟[1] 尚丽新[1] 吴楠[1] 王心[1] 

机构地区：[1]北京军区总医院妇产科,北京100700

出　　处：《中国优生与遗传杂志》2011年第9期69-71,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的通过观察人类白细胞抗原G(HLA-G)在胎膜早破患者与正常妊娠胎盘组织及外周血中的表达差异,探讨HLA-G在母胎耐受中的意义。方法分组:选取本院2010年5月～10月行剖宫产分娩产妇40例,其中胎膜早破组20例(实验组),正常产妇组20例(对照组)。采用流式细胞术检测两组产妇外周血及胎盘组织的HLA-G+的表达情况,比较两组表达差异。结果胎膜早破患者胎盘组织中HLA-G+表达显著低于正常妊娠组,差异有统计学意义(P<0.05)。结论 HLA-G+在胎盘中的低表达可能与胎膜早破的发生有关,对于母胎耐受的维持有意义。Objective： By observing the expression differences of human leukocyte antigen G（HLA-G） between the placenta and peripheral blood from patients with premature rupture of membranes and normal pregnancy,investigate the significance of HLA-G in maternal-fetal tolerance.Methods：Group： Select the 40 cases of maternal cesarean deliveries hospital during the May to October in 2010,including 20 cases of premature rupture of membranes group（experimental group） and 20 cases of normal labor group（control group）.The expression levels of HLA-G＋ in the placenta and peripheral blood from patients with premature rupture of memberanes and normal pregnancy were studied by flow cytometer.Results： Compared with control group,the levels of HLA-G＋ in the placenta from patients with premature rupture of memberanes were lower significantly（P0.05）.Conclusion： The low expression of HLA-G＋ in the placenta may be related to the premature rupture of membranes,meaningful for the maintenance of maternal-fetal tolerance.

关 键 词：人类白细胞抗原G 胎膜早破 母胎耐受 

分 类 号：R714.25[医药卫生—妇产科学]