孕期注射乙肝免疫球蛋白对婴儿anti-HBs产生的影响  

The effect ofhepatitis B immunoglobulin administration during pregnancy in the produce anti-HBs in infants

作　　者：刘洁[1] 李淑红[1] 刘志芬[1] 刘绍菲[1] 贾蓓[1] 董梅[1] 

机构地区：[1]烟台毓璜顶医院产科,山东264009

出　　处：《中国优生与遗传杂志》2011年第10期92-93,55,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨孕期注射乙肝免疫球蛋白的孕妇分娩的婴儿对乙肝疫苗免疫应答情况。方法以HBsAg阳性孕妇及其新生儿为研究对象,孕期母亲注射乙肝免疫球蛋白的300例新生儿为实验组,未使用者80例为对照组,比较两组新生儿出生时及联合免疫后7个月anti-HBs产生情况。结果实验组与对照组婴儿出生时anti-HBs阳性率分别为10.3%(31/300)和1.25%(1/80),差异有统计学意义;7个月龄实验组anti-HBs产生率为96.1%(124/129),对照组anti-HBs产生率95.3%(41/43),差异无统计学意义;出生时anti-HBs阳性的新生儿25例,7个月龄均产生anti-HBs,出生时anti-HBs阴性或弱阳性的147例婴儿中有7例婴儿anti-HBs仍为阴性或弱阳性,差异有统计学意义。结论孕期使用乙肝免疫球蛋白可提高新生儿出生时anti-HBs产生率,但对7个月anti-HBs产生率无影响。Objective：To study the efficacy of hepatitis B immunoglobulin（HBIG） administrated during pregnancy for the infants immune response to hepatitis B vaccine through a follow-up study program.Methods： 300 HBsAg positive pregnant women who were consecutively collected and were administered with HBIG were selected as intervention group,80 HBsAg positive pregnant women who were not administered with HBIG were selected as controls.The titer of anti-HBsAg at birth and 7th months were detected.Results： The rate of detectable anti-HBs in infants was10.3%（31/300）and 1.25%（1/80）among in intervention group and control group.After infants were inmmunized by HBIG combining hepatitis B vaccine,the anti-HBs positive rate reached 96.1%（124/129）and 95.3%（41/43）at 7th months.Of the 17 infants HBsAg positive at birth,HBsAg was found persistently sera positive in 1 neonate at two years old,the liver function is normal,the others all became HBsAg negative at 7th month,among the 147 infants anti-HBs negative at birth,there were 7 infants who had no detective anti-HBs at7th month,however,of the25infants having detective anti-HBs at birth,all infants detected anti-HBs at 7th month.Conclusions： The results of the present study suggested that HBIG administration during pregnancy can raise the rate of anti-HBs at birth but but there is no significance at 7th month.

关 键 词：肝炎病毒 乙型(HBV) 乙肝免疫球蛋白 ANTI-HBS 

分 类 号：R512.62[医药卫生—内科学] R714.2[医药卫生—临床医学]