小檗碱联合达英-35治疗多囊卵巢综合征的疗效观察  

Therapeutic effect of berberine combined with Diane-35 on patients with Polycystic ovary syndrome and insulin resistance

作　　者：隋明[1] 魏巍[2] 王晔 关源源[1,4] 

机构地区：[1]哈尔滨医科大学,哈尔滨150001 [2]哈尔滨医科大学附属第一医院生殖科,哈尔滨150001 [3]哈尔滨市第二医院妇产科,哈尔滨150056 [4]北京协和医院,北京100730

出　　处：《中国优生与遗传杂志》2011年第10期119-121,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的观察小檗碱(BBR)联合达英-35(CPA)对多囊卵巢综合征(PCOS)合并胰岛素抵抗(IR)患者治疗效果。方法将89例PCOS合并IR的不孕症患者随机分成3组,连续用药3个月经周期。采取自身对照及组间对照的方法比较用药前后临床表现、糖代谢和性激素等指标的变化。结果 3组患者经过治疗后体重、BMI、总睾酮较治疗前明显降低;小檗碱组患者空腹血清胰岛素水平、空腹血糖、IR指数、腰臀比、T、LH等指标与二甲双胍组组比较有统计学意义(P<0.05)。结论 PCOS合并IR的患者应用BBR或MET均可明显改善内分泌代谢紊乱。在改善糖代谢方面,二者效果相当,但在改善中心性肥胖和高雄等方面,BBR更具优势。Objective： To observe the therapeutic effect of berberine（BBR）combined with Diane-35 on patients with polycy sticovary syndrome（PCOS） and insulin resistance（IR）.Methods： 89 patients with PCOS and IR were randomly divided into three groups.Therapeutic course was three months.The clinical feature,parameter of reproductive hormone and glycometabolism were observed and calculated at baseline and three months later.Results： After 3 months of treatment,body weight,BMI and the serum T level decreased in both three groups.Compared with baseline,the parameter of glucosem etabolisman,insulin resistance,FIN,T and LH were significantly improved in Berberin group.And there were significant difference between Berberine and Metformin group.Conclusion： Berberine and Metformin are quite effective medicine for the treatment of PCOS and insulin resistance.There is no significant difference about their therapeutic effect on glycometabolism,but Berberine have more advantage on decreasing WHR and T.

关 键 词：多囊卵巢综合症 胰岛素抵抗 小檗碱 二甲双胍 

分 类 号：R711.75[医药卫生—妇产科学]