深圳口岸出入境人员HIV感染情况及其分子特征  

Study on molecular characteristics and situation of HIV infection among entry-exit personnel at Shenzhen port

作　　者：刘胜牙[1] 朱玉兰[1] 李微[1] 刘春芳[1] 张登峰[1] 俞杨[1] 

机构地区：[1]深圳出入境检验检疫局,广东深圳518033

出　　处：《中国国境卫生检疫杂志》2011年第4期217-220,共4页Chinese Journal of Frontier Health and Quarantine

基　　金：国家自然科学基金青年科学基金项目(81102174);国家质检总局科研基金项目(2009IK216)

摘　　要：目的为了揭示深圳口岸出入境人员艾滋病病毒(HIV)感染者的流行病学特征以及HIV亚型的分布情况。方法以1991—2008年深圳国际旅行卫生保健中心HIV确证实验室检测的113例HIV感染者为研究对象,分析了深圳口岸出入境人员艾滋病的流行特征;并对HIV感染者的HIV-1抗体阳性血浆进行HIV基因型分析。结果 HIV感染者以境外人员为主,男性高于女性,感染人员以商人和驾驶员为主,感染群体以青壮年为主,两性接触是主要传播途径,感染者来自26个国家和地区。本研究共获得67份gag基因和68份pol基因序列,共发现9种HIV-1亚型和重组亚型,包括A1、B、C、D和G亚型以及CRF01_AE、CRF02_AG、CRF07_BC和CRF08_BC重组亚型。结论深圳口岸出入境人员HIV的感染和流行呈多样化,我国国境卫生检疫在防控艾滋病传播中已发挥了重要作用。Objective To understand the epidemiological characteristics and subtype of HIV infection among entry-enxit personnel at Shenzhen port. Methods A total of 113 cases with HIV-1-seropositive from 1991 to 2008 and the blood samples of HIV-1-seropositive from 1996 to 2008 at Shenzhen port were investigated on epidemiology surveys and HIV subtype. Results The mainly foreign personnel were infected, men more than women, and businessmen and drivers were main, mainly infected population were young, gender contact was the major route of transmission, the patients were from 26 countries and regions. Phylogenetic analyses performed on 68 pol gene and 67 gag gene sequences revealed that subtype CRF01_AE virus predominated in this population followed by subtype B, with the other non-B subtypes C, CRF08_BC, G, CRF07_BC, CRF02_AG, A1, and D also present. Conclusion This study may help to guide recommendations for tracking dissemination of the pandemic worldwide and the current international control strategies against the HIV-1 epidemic. The frontier health and quarantine has played an important role in the prevention and control of the spread of AIDS.

关 键 词：艾滋病毒 亚型 分子特征 出入境人员 口岸 

分 类 号：R512.91[医药卫生—内科学]