溶液搅拌法制备大豆苷元-羟丙基-β-环糊精包合物的研究  

Preparation of inclusion complex of daidzein and hydropropyl-β-cyclodextrin by solution stirring method

作　　者：周伟[1] 李颖[1] 杨大坚[1] 

机构地区：[1]深圳市中药药学及分子药理学研究重点实验室暨香港理工大学深圳研究院现代中药研究所,广东深圳518057

出　　处：《中南药学》2011年第8期566-571,共6页Central South Pharmacy

基　　金：深圳市科技计划项目(No.JC200903170501A)

摘　　要：目的制备大豆苷元-羟丙基-β-环糊精包合物并考察其表观性质。方法采用正交试验优化大豆苷元-羟丙基-β-环糊精(HP-β-CD)包合物的制备工艺,通过电镜扫描、红外、X射线衍射考察包合物表观性质,并测定了包合物的粒径分布。结果最佳制备工艺为∶HP-β-CD和大豆苷元摩尔比1∶1、温度控制为45℃、包合时间为4 h、HP-β-CD浓度为10%,形成的包合物表观形态好,粒径分布均匀。结论此工艺适合于大豆苷元-HP-β-CD包合物的制备。Objective To prepare the daidzein-hydropropyl-β-cyclodextrin inclusion complex and determine its apparent properties.Methods The optimum processing of inclusion complex was determined by orthogonal design method.The apparent properties of inclusion complex were identified by SEM,IR,and X-ray diffraction,and its particle size was also determined.Results The optimum preparation conditions of inclusion complex were established as follows： the proportion of daidzein and hydropropyl-β-cyclodextrin（HP-β-CD） was 1∶1,the inclusion temperature was 45 ℃,the inclusion time was 4 h,and the concentration of HP-β-CD was 10%.The particle of the inclusion complex had uniform shape and the particle was well-distributed.Conclusion The method can be used to prepare the daidzein-HP-β-CD inclusion complex.

关 键 词：溶液搅拌法 包合物 大豆苷元 羟丙基-肛环糊精 

分 类 号：R944.9[医药卫生—药剂学]