围术期应用参麦注射液对肺癌根治术后患者血浆细胞因子的影响  

Effect of Shenmai Zhusheye on perioperative cytokines in patients with lung cancer after radical resection

作　　者：胡星明[1] 肖高明[1] 陈跃军[1] 王文祥[1] 吴冠宇[1] 周彬[1] 

机构地区：[1]湖南省肿瘤医院胸外科,长沙410013

出　　处：《中南药学》2011年第8期571-573,共3页Central South Pharmacy

摘　　要：目的探讨围术期应用参麦注射液对肺癌根治术后患者血浆细胞因子的影响并探讨可能的机制。方法将62例肺癌患者随机分为观察组和对照组各31例。2组均行肺癌根治术,对照组术中、术后采用常规治疗,观察组在对照组治疗方法的基础上,采用中成药参麦注射液治疗。观察2组术后4 h、1日、3日血浆细胞因子TNF-α、IL-6和IL-10的浓度。结果 TNF-α、IL-6浓度在术后4 h、1日、3日观察组较对照组要低(P<0.05)。IL-10的浓度术后4 h、第1日观察组高于对照组。结论应用参麦注射液能降低促炎细胞因子的水平,提高抗炎细胞因子的水平,减轻肺癌根治术后患者全身炎症反应。Objective To investigate the effect of Shenmai Zhusheye on the plasma cytokines and probable mechanism during the perioperative period for patients after radical resection of pulmonary carcinoma.Methods A total of 62 patients with lung cancer were randomly divided into an experiment group and a control group（n=31）.Both groups had radical resection.The control group received general therapy during the perioperative period,while the experiment group received Shenmai Zhusheye besides general treatment.We observed the concentration of cytokine TNF-α,IL-6,and IL-1 at 4 h on day 1 and day 3 after the surgery.Results The concentration of cytokine TNF-α and IL-6 in the experiment group was lower than that in the control group at 4 h,on day 1 and day 3 after the surgery（P〈0.05）.The concentration of cytokine IL-10 of the experiment group postoperative at 4 h,and on day 1 was higher than that in the control group.Conclusion Shenmai Zhusheye can reduce the level of proinflammatory cytokin,and increase the level of inflammatory cytokine,which can alleviate the systemic inflammation response of the patient after radical resection of pulmonary carcinoma.

关 键 词：肺癌根治术 细胞因子 参麦注射液 全身炎症反应 

分 类 号：R961[医药卫生—药理学] R979.1[医药卫生—药学]