悬浮聚合法制备可降解磁性聚丙交酯微球  

Preparation of degradable magnetic poly (L-Lactide) particles by suspersion polymerization

作　　者：张冬[1] 宋伟[1] 孙志[1] 韩柏[1] 雷清泉[1] 

机构地区：[1]哈尔滨理工大学电气与电子工程学院工程电介质及其应用教育部重点实验室,黑龙江哈尔滨150080

出　　处：《化学工程师》2011年第9期50-53,共4页Chemical Engineer

摘　　要：为了制备以纳米Fe3O4复合聚丙交酯得到聚合物微球,采用丙交酯和纳米级Fe3O4粉为基体,通过悬浮聚合制备可降解磁性聚丙交酯微球,并对其性能进行分析。实验表明通过悬浮聚合方法,合成了聚合物微球。该微球通过红外光谱、电镜、熔点测定等方法表征,确定该产物为目标产物,其粒径为30～50μm,熔点为67℃,分子量为12825。比磁饱和强度бs为17.70emu.g-1,其降解速率测定得知其在20d仍未全部降解,可以作为靶向缓释药物载体使用。For the research of the preparation of degradable magnetic poly （L-Lactide）partieles from the monomer L-lactide and nanomagnetie Fe3O4 particle as main components, in presence of initiator by suspension polymerization. And its properties were analyzed.Experiments show that polymer particles were synthetized through suspension polymerization. The particles were analyzed by IR, SEM, melting point measure and etc. Result showd that the particles were exact the degradable magnetic poly （L-Laetide）partieles. And the particle size is 30 to 50μm, melting point is 67℃ the molecular weight is 12825, magnetic saturation strength6sis 17.70emu·g-1The degradation rate test showd that the particles still didn＇t thoroughly degradate in 20 days ,it can be used as carrier of target control release medicine.

关 键 词：聚丙交酯 纳米四氧化三铁 磁性微球 可降解 

分 类 号：TQ316.33[化学工程—高聚物工业]