慢性阻塞性肺疾病患者急性加重频度相关因素分析  

Analysis of related factors of the frequency of acute exacerbation in COPD patients

作　　者：曹建存[1] 王燕[2] 张丽[1] 辛士珍[1] 马力[2] 

机构地区：[1]天津医科大学研究生院,天津300070 [2]天津医科大学总医院肿瘤科,天津300052

出　　处：《天津医科大学学报》2011年第3期347-348,352,共3页Journal of Tianjin Medical University

基　　金：天津市卫生局科技基金资助项目(09KZ107)

摘　　要：目的:研究慢性阻塞性肺疾病(COPD)患者急性加重频度的相关因素。方法:回顾性分析202例COPD患者近3年COPD急性加重的次数。测定电解质(血清钙,血清磷),行血气分析、肺功能检查;分析血清钙和急性加重次数、血气分析、肺功能指标之间的关系。结果:202例COPD患者中低血清钙组患者占57.92%,其急性加重的频度高于血清钙水平正常组患者(P<0.05)。117例COPD低血清钙组患者中,血清钙水平与年龄、pH呈负相关(r=-0.196,r=-0.908;P均<0.05),与血清磷水平、BMI、Pa-CO2、FEV1%预计值呈正相关(r=0.309,r=0.466,r=0.909,r=0.301;P均<0.05)。结论:COPD患者合并低血清钙时急性加重频度升高,血清钙水平可作为评估COPD严重程度的指标之一。Objective： To study the related factors of the frequency of acute exacerbation in chronic obstructive pulmonary disease （COPD） patients. Methods： The frequency of acute exacerbation in 202 COPD patients was investigated in last 3 years retrospectively, and the level of serum calcium, phosphorus,blood gas analysis, pulmonary function test were determinated.The relations of serum calcium with the frequency of acute exacerbation, values of blood gas analysis, pulmonary function were analyzed. Results： The percent of patients with low serum calcium was 57.92% in 202 patients,the frequency of acute exacerbation in low serum calcium group was higher than that in normal serum calcium group （P〈0.05）. In 117 low serum calcium group patients, the level of serum calcium was negatively correlated with age,pH （r =-0.196, r =-0.908; P〈0.05 completely）;and positively correlated with the level of phosphorus,BMI, PaCO2, FEVI%（ r =0.309, r =0.466, r =0.909, r=0.301; P〈0.05 completely）. Conclusion： The frequency of acute exacerbation is high in low serum calcium group. The level of serum calcium can be used to evaluate the severity of COPD.

关 键 词：慢性阻塞性肺疾病 急性加重 低血清钙 

分 类 号：R563[医药卫生—呼吸系统]