碎裂电位的自主神经机制  

Autonomic Mechanism of Complex Fractionated Atrial Electrogram

作　　者：林玉壁[1] 李自成[1] 张树龙[2] 高连君[2] 

机构地区：[1]暨南大学附属第一医院心内科,广东广州510630 [2]大连医科大学附属第一医院心内科,辽宁大连116011

出　　处：《心血管病学进展》2011年第5期703-707,共5页Advances in Cardiovascular Diseases

基　　金：中央高校基本科研业务费专项资金资助(21611333);暨南大学第一临床医学院重点学科基金(暨一临[2010]4号)

摘　　要：碎裂电位是心房颤动发生和持续的因和果,其机制与心脏自主神经密切相关。心脏内源性和外源性自主神经共同作用,增加心房的早期后除极和钙瞬变,导致碎裂电位和心房颤动发生。因此碎裂电位与自主神经节丛或脂肪垫分布一致。针对自主神经节丛消融,可以减少或消除碎裂电位。Complex fractionated atrial electrogram（CFAE） is the reason and result for the initiation and persistence of atrial fibrillation.It is associated with the cardiac autonomic verves.Either or both of cardiac endogenous and exogenesis autonomic verve activation could increase the early-depolarization and calcium transient,and lead to CFAE and atrial fibrillation.The distribution of CFAE is consistent with that of ganglionated plexus or fat pad.Catheter ablation of ganglionated plexus could decrease or eliminate CFAE.

关 键 词：碎裂电位 自主神经 心房颤动 射频消融 

分 类 号：R541.7[医药卫生—心血管疾病]