邻氯甲苯直接硝化法合成6-氯-3-氨基甲苯-4-磺酸  

Synthesis of 6-chloro-3-aminotoluene-4-sulfonic acid by direct nitration of o-chlorotoluene

作　　者：何二梅[1] 姜日善[1] 

机构地区：[1]延边大学理学院化学系,吉林延吉133002

出　　处：《化学研究与应用》2011年第9期1273-1274,共2页Chemical Research and Application

摘　　要：邻氯甲苯混酸硝化合成6-氯-3-氨基甲苯-4-磺酸(CLT酸)因其产率低及选择性差而未能实现工业生产,本文对该工艺进行了改进,采用酸性β沸石和乙酰硝酸酯作为催化剂和硝化剂,提高了硝化选择性和收率,分别为72%和97%;并改进了还原、异构体分离和磺化操作;CLT酸总收率提高到61%。Because of low yield and poor selectivity,direct nitration of o-chlorotoluene with mixed acid failed to achieve application in industrial synthesis of CLT acid.The use of zeolite-beta in its proton form as catalyist and acetyl nitrate as nitrating agent,increased the yield（97%）and selectivity of nitration（72%）.And reduction,isomer separation and sulfonation process were improved.Overall yield of CLT acid was 61%.

关 键 词：CLT酸 硝化选择性 2-氯-5-氨基甲苯 

分 类 号：O625.75[理学—有机化学]