RNA干扰技术在支气管哮喘研究中的应用  

作　　者：刘春凤[1] 熊瑛[1] 

机构地区：[1]泸州医学院附属医院呼吸内科,四川泸州646000

出　　处：《中国卫生产业》2011年第08X期118-119,共2页China Health Industry

摘　　要：支气管哮喘(Bronchial Asthma,简称哮喘),是由多种细胞特别是肥大细胞、嗜酸性粒细胞和T淋巴细胞参与的慢性气道炎症。目前已知这些细胞都可产生炎症介质,其包括组胺、前列腺素、白三烯、内皮素-1等。如果我们能利用RNA干扰技术从源头上让致病基因"沉默",减轻甚至阻断多种炎症细胞、炎症介质和细胞因子的产生及其相互作用,以减轻气道慢性炎症,从而达到缓解哮喘症状甚至治疗哮喘的目的。本文就RNA干扰技术在哮喘研究中的应用的综述。Bronchial asthma is caused by a variety of cells such as mast cells,eosinophils and T lymphocytes in chronic airway inflammation.A wide variety of cells can generate inflammatory mediators,including histamine,prostaglandins,leukotrienes and endothelin-1.If we can use RNA interference to silent pathogenic gene from the source reduce or even block of inflammatory cells,mediators of inflammation and cytokine production and their interactions,it can alleviate the airway inflammation and relieve asthma symptoms and treatment of bronchial asthma.In this paper,RNA interference in asthma research overview.

关 键 词：RNA干扰 支气管哮喘 

分 类 号：R562.25[医药卫生—呼吸系统]