碘化亚铜/乙二胺催化氮杂环化合物的N-芳基化反应  

N-Arylation of Nitrogen Heterocycles Catalyzed by Copper(Ⅰ) Iodide/Ethylenediamine

作　　者：胡帅帅[1] 郭海昌[1] 蒋华江[1] 郑人华[1] 

机构地区：[1]台州学院医化学院,临海317000

出　　处：《应用化学》2011年第10期1179-1183,共5页Chinese Journal of Applied Chemistry

摘　　要：以碘化亚铜/乙二胺为催化体系,研究了卤代芳烃和氮杂环化合物的Ullmann反应。结果表明,氮杂环化合物的pKa越小,芳基化反应越容易进行,p-π共轭形成的富电子卤代芳烃有利于反应,非p-π共轭的富电子卤代芳烃使反应变难。This paper discussed the Ullmann reaction of aryl halides with nitrogen heterocycles catalyzed by copper（Ⅰ） iodide/ethylenediamine.The results showed that reaction was preferred for nitrogen heterocycles with lower pKa values.In addition,the reactions were also favorable for the electron-rich aryl halides with p-π conjugations,however,they became difficult for other electron-rich aryl halides.

关 键 词：ULLMANN反应 N-芳基化反应 氮杂环化合物 碘化亚铜/乙二胺催化 

分 类 号：O621.3[理学—有机化学]