CD15s抗原在肾移植急性排斥反应中的检测及其临床意义  

Clinical significance of the detection of CD15s antigen in acute rejection after renal transplantation

作　　者：李沙丹[1] 王亮[1] 梁平[1] 李黔生[2] 靳风烁[2] 张克勤[2] 

机构地区：[1]中国人民解放军成都军区总医院泌尿外科,成都610083 [2]第三军医大学大坪医院泌尿外科,重庆400042

出　　处：《国际检验医学杂志》2011年第15期1676-1677,共2页International Journal of Laboratory Medicine

摘　　要：目的探讨CD15s抗原在肾移植急性排斥反应中的检测和临床意义。方法将研究对象分为移植肾功能正常组、急性排斥反应组、其他原因引起移植肾功能不全组、健康对照组,采用流式细胞仪检测外周血淋巴细胞CD15s抗原表达率。各组分别于设定日期后第1、3、7、14、28天各采集标本1次。结果 CD15s抗原在移植肾功能正常组呈先降后升变化,但与其他原因引起肾功能不全组无显著差异;CD15s抗原表达率在急性排斥反应时明显增加(P<0.01),抗排斥治疗后逐渐下降。结论 CD15s抗原作为一项肾移植术后急性排斥反应的检测指标,能够准确反映患者的免疫功能状态。Objective To investigate the clinical significance of the detection of CD15s antigen in acute rejection after renal transplantation. Methods Subjects were divided into 4 groups,including group with normal renal function （group A） ,group with acute rejection （group B）,group with elevated serum level of creatinine but without rejection（group C） and group of heahhy volun teers （group D）. The expression of CD15s antigen was detected by using flow cytometry at 1,3,7,14 and 28 days after settled date. Results The expression of CD15s antigen in group A decreased and then increased,but was not significantly different with group C. The expression of CD15s antigen significantly increased during rejection （P^0.01）, and reduced gradually after anti rejection treatment. Conclusion The dynamic investigation of CD15s expression would be helpful for the diagnosis of rejection and the esli marion of anti-rejection effect,

关 键 词：抗原 CDl5 肾移植 急性排斥反应 

分 类 号：R699[医药卫生—泌尿科学]