慢性咳嗽患者的呼吸道嗜酸性粒细胞性炎性反应特征  

The features of eosinophilic airway inflammation in patients with chronic cough

作　　者：陈慧暖[1] 洪春霖[1] 洪敏俐[1] 郑伟彬[1] 黄小华[1] 陈文喜[1] 高凌云[1] 刘朝辉[2] 

机构地区：[1]福建中医药大学附属漳州市中医院检验科,363000 [2]福建中医药大学

出　　处：《国际检验医学杂志》2011年第14期1538-1539,1542,共3页International Journal of Laboratory Medicine

基　　金：福建省自然科学基金资助项目(2008J0314);福建省中医药科技重点课题资助项目(wzzz0909)

摘　　要：目的探讨慢性咳嗽患者的呼吸道嗜酸性粒细胞炎性反应特征。方法使用诱导痰嗜酸性粒细胞计数检查123例慢性咳嗽患者的呼吸道嗜酸性粒细胞性炎性反应情况,其中咳嗽变异型哮喘(CVA)44例、嗜酸性粒细胞性支气管炎(EB)27例、上气道咳嗽综合征(UACS)26例、变应性咳嗽(AC)17例和胃食管反流相关性咳嗽(GERC)9例。收集56例典型哮喘(CA)患者和25例健康者的诱导痰嗜酸性粒细胞计数结果进行统计学比较。结果慢性咳嗽患者呼吸道嗜酸性粒细胞炎性反应的阳性率为0.487 8(60/123),其中,CVA组和EB组分别为0.750 0(33/44)和1.000 0(27/27),其他病因组均为0.000 0。CVA组与EB组之间的差异具有统计学意义(P=0.005),CVA组与CA组[0.821 4(46/56)]之间的差异无统计学意义(P=0.507),EB组与CA组之间差异具有统计学意义(P=0.019),CVA组、EB组分别与UACS组、AC组、GERC组、健康对照组比较,差异具有统计学意义(P值均为0.000)。呼吸道嗜酸性粒细胞炎性反应患者的诱导痰嗜酸性粒细胞比值,EB组低于CVA组(Z=-2.551,P=0.011)和CA组(Z=-3.190,P=0.001),CVA组与CA组之间差异无统计学意义(Z=-0.801,P=0.423)。结论嗜酸性粒细胞性炎性反应是慢性咳嗽患者的一种主要的呼吸道炎性反应类型,主要见于CVA和EB患者。CVA和EB的呼吸道嗜酸性粒细胞性炎性反应程度不同。Objective To explore the features of eosinophilic airway inflammation in patients with chronic cough. Methods Eo- sinophilic airway inflammation in 123 patients with chronic cough were assessed using the induced sputum eosinophil counts,inclu- ding 44 cases with cough variant asthma（CVA）,27 cases with eosinophilic bronchitis（EB）,26 cases with upper airway cough syn drome（UACS）, 17 cases with atopic cough（AC）, 9 cases with gastroesophageal reflux related cough （GERC）. Difference of induced sputum eosinophil cell counts between chronic cough and healthy controls（n = 25）, chronic cough and classic asthma（CA, n- 56 ） were compared. Results Positive rate of eosinophilic airway inflammation was 0. 487 6（60/123） in patients with chronic cough,a mong whom there were 0. 750 0（33/44） with CVA and 1. 000 0 with EB. Eosinophil airway inflammation was not found in other cause of chronic cough and health controls. Positive rate of eosinopbilic airway inflammation was significantly increased in EB com- pared with CVA （P^0. 005） and CA （P=0. 019） ,but was not significantly different between CVA and CA（P^0. 507）. CVA and EB were significantly increased compared with other cause of chronic cough and health controls respectively（P = 0. 000）. Induced sputum eosinophil ratio was significantly decreased in EB with eosinophil airway inflammation compared with CVA（P= 0. 011） and CA （P=0. 001） ,but was not significantly different between CVA and CA（P=0. 423）. Conclusion Eosinophilic airway inflamma tion was a common type of airway inflammation in chronic cough,which was mainly found in CVA and EB. Severity of eosinophilic airway inflammation were different in EB and CVA.

关 键 词：咳嗽 嗜酸细胞 炎症 气道 

分 类 号：R446.1[医药卫生—诊断学]