骨髓铁与常用血清铁指标的相关性研究  

The relevance research of the routine serum iron indicators and marrow iron

作　　者：魏小平[1] 马泽荣 郑贵星[1] 谭丽[1] 曾哲彤[1] 

机构地区：[1]广州医学院第一附属医院检验科,510120 [2]广东省广州市萝岗区九佛医院检验科,510555

出　　处：《国际检验医学杂志》2011年第14期1546-1547,1549,共3页International Journal of Laboratory Medicine

摘　　要：目的探讨血清铁(SI)、血清铁蛋白(SF)、总铁结合力(TIBC)、不饱和铁结合能力(UIBC)、转铁蛋白(TRF)等血清铁指标和骨髓内、外铁的相关性。方法对112例贫血患者进行骨髓铁染色及血清常用铁指标的检测。将骨髓内、外铁与常用铁指标进行等级相关统计分析。按骨髓内、外铁变化的情况将病例分组:骨髓内、外铁均下降为第1组;骨髓内铁下降、外铁上升为第2组;骨髓内、外铁均上升为第3组,比较不同组之间常用铁指标的差异。结果骨髓内铁与SI相关性最高,呈正相关;骨髓外铁与SF相关性最高,呈正相关。第1、2组SI水平差异无统计学意义(P>0.05);第1、2组与第3组SI水平差异均有统计学意义(P<0.05)。第1组与第2、3组间SF水平差异均有统计学意义(P<0.05);第2、3组间SF水平差异无统计学意义(P>0.05)。3组间两两比较,TRF水平差异均无统计学意义(P>0.05)。结论常用铁指标与骨髓细胞内、外铁具有良好的相关性。综合分析血清铁指标对诊断单纯性缺铁性贫血、慢性病贫血及铁负荷有重要的临床价值。Objective To investigate the relevance between the serum iron （SI） ,serum ferritin （SF） ,total iron binding capacity （TIBC） ,unsaturated iron-binding capacity （UIBC） ,transferrin （TRF） and the marrow iron. Methods Several routine sera iron in- dicators were detected and marrow iron-stain was performed for 112 anemia patients. Furthermore, the results of marrow iron and serum iron indicators were analyzed with rank correlation statistical analysis. According to the variations of inner-iron and outer i- ron,all patients were divided into three groups,including group 1 with decreased inner-iron and decreased outer-iron,group 2 with decreased inner-iron but increased outer-iron and group 3 with increased inne^iron and outer-iron, and the differencse of routine iron indicators were analyzed among these groups. Results The inner-iron was most positively correlated with SI,and outer iron was most positively correlated with iron protein. There was no statistical differencse of SI between group 1 and group 2 （P^0.05）, but there are significant differences between group 3 and 1 ,group 3 and 2 respectively （P^0.05）. For SF,there were significant differ- ence between group 1 and group 2,3 （P^0.05）. There were no significant difference of TRF between all groups （P^0.05）. Con- clusion There could be fine correlation between routine iron indicators and marrow iron. Comprehensively analysis of routine iron indicators is crucial for the diagnosis of IDA, chronic disease anemia and iron overloading.

关 键 词：铁蛋白质类 铁 骨髓铁 铁指标 

分 类 号：R556[医药卫生—血液循环系统疾病]