血清视黄醇结合蛋白4和非酒精性脂肪性肝病的相关性  

The correlation between serum RBP4 and nonalcoholic fatty liver disease

作　　者：孙立山[1] 范列英[1] 王暖[2] 汪明东[1] 陆柳[1] 郑慧雅[1] 

机构地区：[1]同济大学附属东方医院,上海200120 [2]同济大学附属上海肺科医院,上海200433

出　　处：《检验医学》2011年第9期602-605,共4页Laboratory Medicine

摘　　要：目的分析非酒精性脂肪性肝病(NAFLD)患者血清视黄醇结合蛋白4(RBP4)水平,探讨血清RBP4与NAFLD发病的相关性。方法分别测定324例NAFLD患者和200名健康对照者血清RBP4、肌酐(Cr)、三酰甘油(TG)、胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹葡萄糖(Glu)水平,比较各指标在2组中的差异。结果 NAFLD组血清RBP4水平[(58.42±20.74)mg/L]明显高于对照组[(39.1±7.1)mg/L](P<0.01);Logistic回归分析显示血清RBP4是与NAFLD发病相关的独立危险因子(预期比数比为1.138,P<0.05),Pearson相关分析提示血清RBP4水平与Cr、TC、TG、LDL-C水平呈正相关(r分别为0.270、0.393、0.175、0.158,P均0.057),与HDL-C水平呈负相关(r=-0.186,P<0.05)。结论血清RBP4水平与NAFLD患病相关,并且与Cr、TC、TG、LDL-C、HDL-C具有相关性。Objective To investigate the correlation between serum retinol binding protein 4（RBP4） and nonalcoholic fatty liver disease（NAFLD） with measuring the levels of RBP4 in serum of patients with NAFLD.Methods RBP4,creatinine（Cr）,triglyceride（TG）,total cholesterol（TC）,high density lipoprotein cholesterol（HDL-C）,low density lipoprotein cholesterol（LDL-C） and fasting glucose（Glu） were measured in serum samples of 324 patients with NAFLD and 200 healthy control subjects.The difference of these biomarkers between the 2 groups were compared.Results Serum RBP4 levels were significantly higher in NAFLD patients [（58.42±20.74） mg/L]compared with healthy control subjects[（39.1±7.1） mg/L]（P0.01）.In Logistic regression analysis,serum RBP4 level was an independent risk factor for the incidence of NAFLD（predictive adds ratio=1.138,P0.05）.In Pearson correlation analysis,serum RBP4 level was positively correlated with levels of Cr,TC,TG and LDL-C（r=0.270,0.393,0.175 and 0.158,P0.05）,but it was negatively correlated with HDL-C level（r=-0.186,P0.05）.Conclusions Serum RBP4 levels are significantly correlated with NAFLD,and there are correlations with Cr,TC,TG,LDL-C and HDL-C.

关 键 词：视黄醇结合蛋白4 血脂 非酒精性脂肪性肝病 

分 类 号：R446.1[医药卫生—诊断学]