短期CPAP干预治疗妊娠合并中重度OSAHS患者的疗效观察  

Interventional efficacy of the short-term CPAP therapy on pregnancy with moderate to severe OSAHS patients

作　　者：徐仲[1] 李涛平[2] 叶红[2] 陈敦金[1] 

机构地区：[1]广州市重症孕产妇救治中心广州医学院第三附属医院产科,广东广州510515 [2]南方医科大学附属南方医院睡眠中心,广东广州510150

出　　处：《中华肺部疾病杂志（电子版）》2011年第4期33-36,共4页Chinese Journal of Lung Diseases(Electronic Edition)

基　　金：广东省医学科研基金资助项目(A2009296)

摘　　要：目的评估对妊娠合并阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者应用短期持续气道正压通气(CPAP)干预的疗效。方法选择妊娠合并中、重度OSAHS患者45例,进行为期一周的CPAP治疗,并在治疗前、后记录患者相关指标。结果妊娠合并OSAHS患者CPAP治疗前平均动脉压(MBP)与尿蛋白、晚期氧化蛋白产物(AOPP)、白细胞介素-6(IL-6)和呼吸暂停通气指数(AHI)呈正相关;与LSaO2呈负相关;经CPAP干预治疗一周后,患者的MBP、AHI、最低SaO2、尿蛋白、IL-6、AOPP均较治疗前有明显改善,差异有统计学意义(P<0.01)。结论短期CPAP治疗可通过降低机体的氧化应激与炎症反应水平,从而达到控制妊娠合并OSAHS患者继发出现妊娠期高血压疾病(HDCP)的目的,且患者具良好的耐受性,是一种非药物治疗HDCP的无创手段,可以在临床上逐步推广。Objective To assess the interventional efficacy of the short-term continuous positive airway pressure （CPAP） therapy on pregnancy with moderate to severe obstructive sleep ap nea hypopnea syndrome （OSAHS） patients. Method 45 pregnancy with moderate to severe OSAHS patients had been ehoosen to have CPAP treatment for a week in progress, before and after the treatment related indicators were recorded. Results The MBP and the urinary protein, AOPP, IL-6, AHI were positively correlated; On the other hand, the MBP and the LSaO2 were negative correlation of pregnancy with OSAHS patients before the CPAP treatment ; the difference was statistically significant （P 〈 0. 01 ）. Conclusion The body＇s inflammatory response and oxidative stress could be reduced by short-term CPAP treatment and the same way thus to control the level of the hypertensive disorder complicating pregnancy（HDCP） ; because of the non-invasive means, all of the patients had good tolerance, and the CPAP can extend to clinical gradually.

关 键 词：低通气综合征 睡眠呼吸暂停 阻塞性 高血压 妊娠 持续气道正压通气 氧化应激 炎症反应 

分 类 号：R563[医药卫生—呼吸系统]