聚乙二醇-水介质中水溶性膦稳定的钌催化芳香酮的不对称加氢反应  

Asymmetric Hydrogenation of Aromatic Ketones Catalyzed by Achiral Monophosphine TPPTS-Stabilized Ru in PEG-Water

作　　者：秦瑞香[1] 王金波[1,2] 熊伟[1] 刘德蓉[1] 冯建[1] 陈华[2] 

机构地区：[1]重庆科技学院化学化工学院,重庆401331 [2]四川大学化学学院,绿色化学及技术教育部重点实验室,四川成都610064

出　　处：《催化学报》2011年第9期1490-1495,共6页

基　　金：重庆市自然科学基金(2010BB8280);重庆市教委科学技术研究项目(KJ101410)~~

摘　　要：在聚乙二醇-400-水介质中,以(1S,2S)-1,2-二苯基乙二胺的磺酸钠盐为手性修饰剂,考察了水溶性三(间-磺酸钠苯基)膦稳定的Ru催化苯乙酮及其衍生物的不对称加氢反应.结果表明,该催化剂体系具有良好的催化活性和对映选择性.在优化反应条件下,苯乙酮转化率和对映选择性分别为100%和84.9%.经正己烷萃取后,催化剂即可从产物中分离出来,并可重复使用多次.PEG-400 was found to be a green and recyclable reaction medium for asymmetric hydrogenation of aromatic ketones catalyzed by achiral monophosphine TPPTS （P（m-C6H4SO3Na）3）, stabilized ruthenium modified by （1S,2S）-DPENDS （DPENDS： disodium salt of sulfonated （1S,2S）-1,2-diphenyl-1,2-ethylene-diamine）. A 84.9% ee was obtained for acetophenone under the optimized conditions. The resulting products can be easily separated from the catalyst by extraction with n-hexane. The catalyst immobilized on PEG-400 not only exhibits excellent activity and enantioselectivity but also can be recycled and reused several times without loss of activity and enantioselectivity.

关 键 词：水溶性膦稳定的钌 芳香酮 不对称加氢 芳香仲醇 聚乙二醇-水 

分 类 号：TQ203.2[化学工程—有机化工]