常用内分泌疾病治疗药物对肝脏的影响  

Influence of common used endocrine therapeutic agents on liver

作　　者：蔡晓波[1] 范建高[2] 

机构地区：[1]上海交通大学附属第一人民医院消化内科,上海200080 [2]上海交通大学医学院附属新华医院消化内科,上海200092

出　　处：《世界临床药物》2011年第9期518-520,525,共4页World Clinical Drug

基　　金：上海市科委重点项目(编号:10411956300);国家自然科学基金(编号:81070322);国家科技部973项目课题(编号:2012CBN17501)

摘　　要：多种内分泌疾病治疗药物可能有潜在肝脏毒性,而内分泌疾病本身也可能引起或加重肝脏损伤。因此,内分泌疾病患者口服治疗原发病药物期间如发生肝功能损害,需仔细鉴别肝损原因。本文综述抗甲亢药物、口服降糖药和他汀类药物对肝脏的影响。Many therapeutic agents for endocrine and metabolic diseases may have potential liver toxicity. However, endocrine diseases also cause or aggravate liver injury. Therefore, as long as liver injury appears among the patients with oral therapeutic drugs for endocrine diseases, the first step should be to identify the causes of liver injury. This review introduces the influence of anti-hyperthyroidism drugs, oral hypoglycemic agents as well as statins on liver.

关 键 词：甲状腺功能亢进 糖尿病 高脂血症 药物性肝损害 

分 类 号：R977.14[医药卫生—药品] R977.15[医药卫生—药学]