氨氯地平联合贝那普利治疗老年原发性高血压效果观察  

Clinical Observation of Amlodipine Combined with Benazepril in Treatment of Senior Patients with Essential Hypertension

作　　者：崔卫华[1] 黄通瑞[1] 齐丽娟[1] 李萌[2] 

机构地区：[1]解放军白求恩国际和平医院老年病科,石家庄050082 [2]解放军总医院第304临床部药剂药理科,北京100048

出　　处：《临床误诊误治》2011年第9期10-12,共3页Clinical Misdiagnosis & Mistherapy

摘　　要：目的探讨氨氯地平联合贝那普利治疗老年原发性高血压的效果。方法选择我院住院或门诊明确诊断的老年原发性高血压60例,随机分为观察组与对照组各30例。对照组予氨氯地平治疗。观察组在此基础上加用贝那普利。两组均连续用药8周。观察两组临床疗效。结果两组治疗后舒张压和收缩压均明显下降,与治疗前比较差异均有统计学意义(P<0.01),治疗后两组间血压比较差异均有统计学意义(P<0.05);观察组总有效率为96.7%,对照组为83.3%,两组比较差异有统计学意义(P<0.05)。结论氨氯地平联合贝那普利治疗老年原发性高血压效果优于氨氯地平单独用药,且不良反应轻微。Objective To investigate the effects of amlodipine combined with benazepril in treatment of senior patients with essential hypertension.Methods 60 senior patients with essential hypertension enrolled from the inpatient and outpatient departments of our hospital were randomly divided into observation group and control group（30 in each group）.Patients in the observation group were treated with Amlodipine and Benazepril for 8 weeks,and patients in the control group were treated with only Amlodipine.The clinical effect was observed.Results Diastolic and systolic blood pressure were significant lower than that of pre-treatment in the two groups（P〈0.01）,there were significant differences of blood pressure between the two groups（P〈0.05）,and there was significant difference in total efficacy between observation group（96.7%） and control group（83.3%）（P〈0.05）.Conclusion The effects of Amlodipine combined with Benazepril are better than Amlodipine alone on blood pressure control with slight side effects.

关 键 词：老年人 原发性高血压 药物疗法 氨氯地平 贝那普利 

分 类 号：R544.11[医药卫生—心血管疾病]