三种方法求解药物溶出度Weibull分布参数的探讨  

Comparison of Three Methods on Drug Dissolution Based on Parameters of Weibull Distribution

作　　者：郭剑伟[1] 吴俊珠[1] 王成军[1] 高鹏飞[1] 缪菊莲[1] 杨志勇[1] 

机构地区：[1]大理学院药学与化学学院,云南大理671000

出　　处：《大理学院学报（综合版）》2011年第8期1-4,共4页Journal of Dali University

摘　　要：目的:探讨3种方法求算药物溶出度Weibull分布参数的结果差别。方法:分别采用计算器、EXCEL和SPSS软件处理药物溶出数据。结果:3种方法计算得到的T50、Td值和Weibull分布参数m值很接近,但参数г和t0间相差较大。结论:药物溶出度Weibull分布参数的计算结果在准确度上SPSS法>EXCEL法>计算器法。Objective： To investigate different results through three methods of solving drug dissolution based on Weibull＇s distribution parameter.Method： The data of drug dissolution based on Weibull＇s distribution were treated with statistic calculator,Microsoft Excel and SPSS software respectively.Result： T50,Td and m values were close in three methods,but г and t0 values were much different.Conclusion： Data from SPSS have shown highest accurate,EXCEL method was less accurate,statistic calculator was the most unreliable method.

关 键 词：药物溶出度 WEIBULL分布 统计计算器 EXCEL SPSS 

分 类 号：R927.11[医药卫生—药学] TP391.13[自动化与计算机技术—计算机应用技术]