经皮冠状动脉介入治疗前后妊娠相关血浆蛋白A的变化  

Change of pregnency associated plasma protein A level after PCI

作　　者：王月海[1] 蔡运昌[2] 张陈匀[2] 杨天和[2] 

机构地区：[1]福建医科大学附属第二医院心内科,福建泉州362000 [2]贵州省人民医院心血管病医院心内科

出　　处：《临床心血管病杂志》2011年第9期683-685,共3页Journal of Clinical Cardiology

摘　　要：目的:观察经皮冠状动脉介入(PCI)治疗所致外周血妊娠相关血浆蛋白A(cPAPP-A)水平的变化。方法:应用ELISA法检测20例冠心病(CAD,CAD组)患者PCI术前及术后20h、30h的cPAPP-A水平,另23例冠状动脉造影(CAG)正常的人群(对照组)为对照。结果:CAD组术后20hcPAPP-A水平(6.61±2.56)μg/L,与术前[(3.82±1.41)μg/L、对照组(3.72±1.52)μg/L]比较,均差异有统计学意义;术后30h(4.92±1.35)μg/L,显著下降,但仍显著高于术前。结论:PCI引发斑块破裂可导cPAPP-A水平升高。Objective：To observe the change of pregnency associated plasma protein A（cPAPP-A） levels following coronary plaque rupture induced by percutaneous coronary stent implantation（PCI）,to explore the causality between the change of cPAPP-A levels and plaque rupture. Method：The cPAPP-A levels of 23 cases without CAD and 20 patients with CAD before PCI and 20 h,30 h after PCI were measured and analysed. Result：cPAPP-A levels of CAD group were significantly increased at 20 h（[6.61±2.56]μg/L） after PCI（P0.01）,but were significantly decreased at 30 h（[4.92±1.35]μg/L） after PCI（P0.05）,still were significantly increased than that（[3.82±1.41]μg/L） before PCI（P0.05）. Conclusion：Coronary plaques rupture induced by PCI could lead to higher cPAPP-A levels,early detection of cPAPP-A is possibly helpful to early diagnosis of acute coronary syndrome.

关 键 词：冠心病 斑块破裂 外周血妊娠相关血浆蛋白A 经皮冠状动脉介入治疗 

分 类 号：R541.4[医药卫生—心血管疾病]