2000～2010年间4960例慢性阻塞性肺病住院患者合并高血压和糖/脂代谢紊乱情况调查  

Prevalence of hypertension and glucose/lipid metabolism disorders in 4960 inpatients with chronic obstructive pulmonary disease during 2000-2010

作　　者：崔华[1] 魏致民 蔡建芳[3] 李毅[4] 范利[1] 胡亦新[1] 刘霖[1] 张梦[1] 刘爱民[5] 

机构地区：[1]解放军总医院南楼心血管二科,北京100853 [2]总参警卫局卫生保健处,北京100017 [3]北京协和医院肾内科,北京100005 [4]卫生部北京医院呼吸科,北京100730 [5]北京协和医院病案室,北京100005

出　　处：《南方医科大学学报》2011年第9期1498-1503,共6页Journal of Southern Medical University

基　　金：全军医药卫生科研基金课题(06MA290)

摘　　要：目的研究慢性阻塞性肺病（COPD）住院患者合并高血压和糖/脂代谢紊乱的患病比例、人群分布特征和顺位及与年龄和性别的相关性研究。方法对2000年1月1日~2010年3月20日间解放军总医院、北京协和医院及卫生部北京医院的住院病案数据库进行回顾性现况调查。结果（1）入选患者4960例,男性3570例,女性1390例,平均年龄（72.2±10.4）岁。（2）高血压、糖尿病/糖耐量异常和高脂血症/脂蛋白代谢紊乱合并症患病比例在COPD患者由高到低顺位为高血压病〉糖尿病/糖耐量异常〉高脂血症/脂蛋白代谢紊乱,分别为40.3%、18.8%和6.9%。且随年龄增长逐渐升高,而合并高脂血症/脂蛋白代谢紊乱的患病比例在≥80岁组却明显下降。（3）女性和男性COPD患者合并高血压的患病比例均随年龄增长而增加,在40~49.9年龄段,不同性别COPD患者合并高血压的患病比例无显著差异（P〉0.05）;从50岁以上各年龄组,女性COPD患者合并高血压的患病比例均显著高于男性（P〈0.05）。（4）男性糖尿病/糖耐量异常的患病比例也呈增龄性改变,但女性在年龄≥80岁后,合并糖尿病/糖耐量异常的患病比例降低（P〈0.05）。不同年龄组COPD患者中男女患病比例的差别从60岁以后开始出现,在60~69.9岁、70~79.9岁两个年龄段,女性合并糖尿病/糖耐量异常的患病比例高于男性（P〈0.05）;≥80岁女性患病比例降低但与男性比较无统计学差异（P〉0.05）。（5）男性和女性在≤80岁的COPD患者合并高脂血症/脂蛋白代谢紊乱的患病比例均随年龄增加而升高（P〈0.05）,且在60~69.9岁、70~79.9岁两个年龄段女性合并高脂血症/脂蛋白代谢紊乱的患病比例高于男性,有统计学意义（P〈0.05）;在≥80岁组男性和女性的患病比例均降低,但无性别差异（P〉0.05）。结论 4960例40岁以上COPD住院患者合并高血压和糖/脂代谢紊乱的患病比例与�Objective To study the prevalence of hypertension and glucose/lipid metabolism induced by chronic obstructive pulmonary disease（COPD） in hospitalized patients and their correlations to age and gender.Methods A retrospectively prevalence survey was conducted among the in-patients with COPD treated in General Hospital of PLA,Peking Union Medical College Hospital and Beijing Hospital between January 1st,2000 and March 20th,2010.Results A total of 4960 COPD patients were selected,including 3570 male and 1390 female patients with a mean age of 72.2±10.4 years.Among these patients,hypertension had the highest prevalence（40.3%）,followed by diabetes/impaired glucose tolerance（18.8%） and then by hyperlipidemia/fat protein metabolism（6.9%）.The prevalence of hyperlipidemia/lipoprotein metabolism in the COPD patients over 80 years old decreased significantly with age.The prevalence of hypertension increased with age.In patients over 50 years old,the prevalence of hypertension was significantly higher in female than in male patients（P〈0.05）.The prevalence of diabetes/impaired glucose tolerance increased with age in male patients but decreased in female patients aged ≥80 years（P〈0.05）.Female patients in 60-69.9 and 70-79.9 years groups had significantly higher incidence of diabetes/impaired glucose tolerance than male patients（P〈0.05）,but not at older ages.The incidence of hyperlipidemia/lipoprotein metabolism disorder increased with age in both male and female patients aged below 80 years（P〈0.05）,but in 60-69.9 and 70-79.9 year groups,female patients had a significantly higher incidence than male patients（P〈0.05）;at the ages ≥80 years,the incidences was lowered in both women and men without a gender-specific differences（P〉0.05）.Conclusions The data we obtained concerning the prevalence of hypertension and glucose/lipid metabolism disorder,age distribution,and gender characteristics of the COPD patients provide a clear target for secondary prevention of COPD.

关 键 词：患病比例 病例调查 慢性阻塞性肺疾病 高血压 糖代谢紊乱 脂代谢紊乱 

分 类 号：R563.9[医药卫生—呼吸系统] R544.1[医药卫生—内科学]