亲水型鼻内窥镜防雾剂的研制  

Development of a hydrophilic antifogging agent for nasal endoscopy

作　　者：万良财[1] 谢民强[1] 符小艺[2] 江珊珊[1] 冼献清[1] 

机构地区：[1]南方医科大学珠江医院耳鼻喉科,广东广州510282 [2]华南理工大学材料学院,广东广州510641

出　　处：《南方医科大学学报》2011年第9期1521-1525,共5页Journal of Southern Medical University

基　　金：国家高技术研究发展计划(83计划)(2007AA021907)~~

摘　　要：目的研制一种防雾时间长、透明无毒、无刺激性的鼻内窥镜防雾剂。方法采用正交试验制得27种配比不同的无色透明、无刺激性鼻内窥镜防雾剂,pH7~8。采用Storz00鼻内镜及显像系统按照鼻内窥镜手术时方式对受试者进行防雾剂防雾测试3次,取平均值即为防雾时间,对同一受试者同时将医用安尔碘、95%酒精作为鼻内镜防雾剂测试3次。结果所研制的鼻内镜防雾剂其最佳配比为：无水乙醇为20%,丙二醇为10%,月桂醇聚氧乙烯醚为20%,十二烷基硫酸钠4%,聚乙二醇4%,余为去离子水,其防雾时间为15 min,明显较医用安尔碘（4 min）、95%酒精（18 s）防雾时间长。结论研制的鼻内镜防雾剂透光度好,无色,安全,防雾时间长,其原因是防雾剂在鼻内窥镜镜头蓝宝石表面形成一层透明均匀的膜。Objective To develop a transparent,non-toxic,non-irritating antifogging agent with long-lasting effect for nasal endoscopy.Methods The antifogging agent was prepared by mixing ethanol,propylene glycol,polyoxyethylene lauryl ether,sodium dodecyl sulfate,polyethylene glycol 400 and deionized water at different proportions based on an orthogonal test design.Twenty-seven test samples of the antifogging agents were obtained,which were colorless,transparent,and non-irritating,with a pH value of 7-8.Storz00 nasal endoscopy and its imaging system were used to test the antifogging time of the 27 samples,and each agent was tested for 3 times with medical Seoul iodine and 95% ethanol as control.Results The optimal composition of the antifogging agent was 20% ethanol,10% propylene glycol,20% polyoxyethylene lauryl ether,4% sodium dodecyl sulfate,4% polyethylene glycol,42% deionized water.The antifogging time of this agent reached 15 min,significantly longer than that of medical Seoul iodine（4 min） and 95% ethanol（18 s）.Conclusion This antifogging agent for nasal endoscopes is colorless and safe and has a long anti-fogging time by forming a homogenous transparent membrane over the endoscopic lens.

关 键 词：亲水 鼻内窥镜 防雾剂 防雾时间 

分 类 号：R943[医药卫生—药剂学]