体检人群骨量改变与踝臂脉搏波传导速度相关性初步探讨  

The preliminary investigation of the correlation between bone mass and ankle-brachial pulse wave velocity in healthy people

作　　者：谢桂云 李强 宋悦 钱振福 杨鸿兵 

机构地区：[1]密云县中医医院,北京101500

出　　处：《中国骨质疏松杂志》2011年第9期808-813,共6页Chinese Journal of Osteoporosis

摘　　要：目的探讨体检人群骨量改变与踝臂脉搏波传导速度(bapwv)的相关性。方法 :选择同时进行骨密度(BMD)和动脉硬化(bapwv)检查的体检人群为数据基础,按性别、年龄、每5岁为一年龄段分组、统计分析BMD和bapwv的检测结果。结果 :男女峰值骨量出现在35岁,男性高于女性,40岁开始出现骨量丢失,且骨量与年龄成负相关性;男女动脉硬化出现在50岁,动脉硬化与年龄成正相关性;动脉硬化几率大于骨量减低的发生几率,男性动脉硬化和骨量丢失的发病率大于女性,分别为36.73%、27.29%和28.27、19.47%,;骨量丢失与动脉硬化的程度均随年龄的增长而加重;骨量丢失出现早于动脉硬化;男女骨量正常者动脉硬化的发生率分别为31.62%、19.21%,骨量减低者动脉硬化的发生率分别为50.34%、65.75%,动脉正常者骨量减低的发生率分别为21.42%、9.29%,动脉硬化者骨量减低的发生率分别为37.50%、45.28%。动脉硬化在骨量减低中的发生率大于骨量正常中的发生率,骨量改变对动脉硬化的影响更显著;两种疾病可以同时存在,男女分别为13.74%和12.80%无明显差异。进行相关性分析男性r=0.234(50岁以后r=0.340),女性r=0.410(50岁以后r=0.439)。通过单因素logistics回归分析,得出男性骨密度降低对动脉硬化产生的风险增加39%,女性骨密度降低动脉硬化风险增加69%。结论 :骨量丢失与动脉硬化有正相关性,年龄越大相关性越密切,骨量丢失与动脉硬化可以并存,提示两者可能互相影响或存在共同的危险因素,有待进一步深入研究。Objective To investigate the correlation between bone mass and ankle-braehial pulse wave velocity （bapwv） in healthy people. Methods People who were undertaken bone mineral density （BMD） test and arteriosclerosis exam were selected to set a data base. They were grouped according to sex and age. The resuhs of BMD and bapwv were statistically analyzed. Results The peak bone mass occurred at 35 years old both in the male and female. It was higher in the male than in the female. The bone mass started to loss from 40 years of age, and it was negatively correlated with age. Arteriosclerosis started from 50 years of age both in male and female. It was positively correlated with age. The incidence of arteriosclerosis was higher than that of bone mass loss. The incidence of arteriosclerosis in males and females with normal bone mass was 31.62% and 19.21% , respectively. It was 50.32% and 65.75% in males and females with bone mass loss, respectively. The incidence of bone mass loss in males and females with normal artery status was 21.42% and 9.29% , respectively. It was 37.50% and 45.28% in males and females with arteriosclerosis. The change of bone mass significantly impacted arteriosclerosis. The two diseases could exist simultaneously. It was 13.74% and 12.80% in males and females without significant difference. The correlation analysis showed r = 0. 234 in males （r = 0. 340 for over 50s） and r = 0. 410 in females （r = 0. 439 for over 50s）. The risk of arteriosclerosis for bone mass loss increased 39% in males and 69% in females by single factor logistics analysis. Conclusion Bone loss is positively correlated with arteriosclerosis. The correlation is getting closer along with aging. Bone mass loss can co-exist with arteriosclerosis, suggesting that they impact each other and they may be influenced by common factors that need to be explored.

关 键 词：骨密度(BMD) 骨量减低 踝臂脉搏波传导速度(bapwv) 动脉硬化 

分 类 号：R681[医药卫生—骨科学]