蜕膜与绒毛组织中血管内皮生长因子及血小板活化因子受体的表达与早期自然流产相关性  

Correlation study of the expression of VEGF and PAF-R in the decidua and villus of patients with early spontaneous abortion

作　　者：徐俊 冯春宇 周俊 郑坚 何兰 林子 周伟新 

机构地区：[1]深圳市龙岗区第二人民医院妇产科,广东深圳518112

出　　处：《海南医学》2011年第18期10-12,共3页Hainan Medical Journal

基　　金：2010年度深圳市科技计划项目(编号:201003406);2010年度深圳市龙岗区医疗卫生科技计划项目(编号:YLL2010010)

摘　　要：目的研究血管内皮生长因子(VEGF)与血小板活化因子受体(PAF-R)在正常早期妊娠及早期自然流产患者蜕膜及绒毛组织中的表达,探讨其与早期自然流产的相关性。方法选取2008年1月至2009年12月在我院妇产科就诊的60例患者作为研究对象,分为正常早孕人流组(A组)、先兆流产组(B组)、稽留流产组(C组)各20例;采用免疫组化技术对VEGF、PAF-R在三组蜕膜及绒毛组织中的表达进行组织学检查及定量分析。结果 (1)三组蜕膜及绒毛组织中VEGF、PAF-R均有阳性表达。(2)VEGF表达量:A组>B组>C组(P<0.05)。(3)PAF-R表达量:A组>B组>C组(P<0.05)。结论早期自然流产患者存在VEGF、PAF-R表达水平的降低,VEGF、PAF-R表达水平的改变可能是导致早期自然流产的重要原因。Objective To investigate the expression levels of vascular endothelial growth factor （VEGF） and platelet activate factor receptor （PAF-R） in the decidua and villus of patients with normal early pregnancy and early spontaneous abortion,and to study the correlation between the expression of VEGF/PAF-R and early spontaneous abortion.Methods 60 patients admitted in the department of obstetrics and gynaecology in our hospital from January 2008 to December 2009 were assigned into three groups：group A （20 cases of induced abortion）,group B （20 cases of threatened abortion） and group C （20 cases of missed abortion）.Immunohistochemical techniques were used to investigate the expression levels of VEGF,PAF-R of histological in the three groups.Results Expressions of VEGF,PAF-R were found positive in decidua and villus tissue in all the three groups.The level of VEGF in group A is the highest,then follows group B and group C （P0.05）.The levels of PAF-R is highest in group A,and lowest in group C （P0.05）.Conclusion The expression level of VEGF and PAF-R were relatively low in patients with early spontaneous abortion,which might be an important factor that leads to early spontaneous abortion.

关 键 词：血管内皮生长因子 血小板活化因子受体 早期自然流产 绒毛 蜕膜 

分 类 号：R714.21[医药卫生—妇产科学]