海洋Penicillium属化学成分与生物活性的研究  

Study on chemical composition and bioactivity of marine penicillium genus

作　　者：余玥[1,2] 林文翰[3] 

机构地区：[1]哈尔滨商业大学生命科学与环境科学研究中心,哈尔滨150076 [2]国家教育部抗肿瘤天然药物工程研究中心,哈尔滨150076 [3]北京大学天然药物及仿生药物国家重点实验室,北京100083

出　　处：《哈尔滨商业大学学报（自然科学版）》2011年第4期517-523,527,共8页Journal of Harbin University of Commerce：Natural Sciences Edition

摘　　要：海洋微生物数量大,种类多,代谢产物多样化,构型奇特,很多具有很好的活性.由于海洋环境的特殊性,海洋微生物发展出其独特的代谢方式,有很多陆地微生物所未遇见过的新型代谢产物.青霉菌在海洋环境中被造就其独特的代谢方式,其生物活性与结构类别都与陆地青霉菌属有很大差异.根据化合物结构类型阐述了近年来在海洋中分离得到的青霉菌属代谢产物的研究概况.Marine microorganisms have a large quantity and variety;the metabolites are diverse with peculiar configurations,many of which have fair activities.Because of the particularity of marine environment,marine microorganisms have developed a unique metabolic pathway of their own,and brought in a large number of new types of metabolites that have never been seen in the land microorganisms.Penicilliums form a unique metabolic pathway in the marine environment,and its bioactivities and structure classifications differ a lot from that of land penicilliums genus.In this paper,brief reviews of recent studies on penicilliums genus separated from the marine were provided according to the structure type of metabolites.

关 键 词：海洋青霉菌属 化学成分 生物活性 

分 类 号：R284[医药卫生—中药学]