暴露小剂量照射的居民血清甲状旁腺激素水平分析  

Levels of serum parathyroid hormone in residents with low-dose radiation exposure

作　　者：邵云平[1] 牛昊巍[2] 傅颖华[2] 孙全富[2] 秋叶澄伯[3] 

机构地区：[1]北京协和医学院公共卫生学院,北京102200 [2]中国疾病预防控制中心辐射防护与核安全医学所 [3]鹿儿岛大学医学和齿学研究生院

出　　处：《中国预防医学杂志》2011年第9期748-750,共3页Chinese Preventive Medicine

基　　金：卫生行业科研专项项目(201002009)

摘　　要：目的了解接受低水平电离辐射长期照射的阳江高本底地区居民的血清甲状旁腺素水平。方法选取长期居住于高本底地区（HBRA）和对照地区（CA）的40~65岁男性居民为研究对象。问卷调查后,采集空腹外周静脉血,用ELISA测定全段甲状旁腺素（iPTH）。结果经多元回归分析,血清甲状旁腺激素（PTH）浓度与个人累积剂量呈负相关。PTH=-9.81×dose＋4.53,P=0.025,差异有统计学意义。结论长期小剂量照射可能影响甲状旁腺素水平。Objective The objective of this study is to evaluate the levels of serum parathyroid hormone in Yangjiang where residents suffered long-term exposure to low levels of ionizing radiation.Methods Blood samples were collected from healthy male residents aged 40～65 who lived in Tangkou,Yangix（the highest dose rate areas in Yangjiang）,Hengpi and Enping（control areas）.Intact parathyroid hormone（iPTH） was tested by the method of enzyme-linked immunosorbent assay（ELISA）.Results The model of multiple regression analysis showed a negative correlation between the levels of serum parathyroid hormone concentration and individual cumulative dose（P0.05）.The mathematic formula is：PTH=-9.81＊dose＋4.53.Conclusion Long-term low-dose radiation exposure may affect the parathyroid hormone levels.

关 键 词：小剂量照射 甲状旁腺激素 全段甲状旁腺素 

分 类 号：R144[医药卫生—公共卫生与预防医学]