二甲基甲酰胺毒性的研究进展  

Toxicity of N,N-dimethylformamide: a review of recent studies

作　　者：夏玉婷[1] 陈晓东[1] 王彩生[1] 束长亮[1] 汪旸[1] 

机构地区：[1]江苏省疾病预防控制中心环境疾病(地方病)防制科,江苏南京210019

出　　处：《环境与健康杂志》2011年第9期842-845,共4页Journal of Environment and Health

基　　金：国家自然科学基金(30901222)

摘　　要：二甲基甲酰胺(N,N-dimethylformamide,DMF)因其溶解能力强而被广泛应用于工业企业。DMF可经呼吸道和皮肤进入机体,损害肝脏、肾脏、胃以及生殖系统、免疫系统等多个器官(系统)。不同人群对DMF毒性的易感性不同,这可能与基因多态性有关。该文综述了DMF对各个器官(系统)的损害机制,为岗前筛选和DMF职业中毒的防护提供理论依据。N,N-dimethylformamide （DMF）, for its strong solvency, is widely used in the industry. DMF can enter the body through the respiratory tract and skin, and damage the liver, kidneys, stomach and reproductive system, the immune system, and the other organs or system. The susceptibility to DMF is not the same in different people,this may be related with gene polymorphism. This article summarized the damage mechanism of DMF in organs or system.

关 键 词：二甲基甲酰胺 代谢 基因多态性 

分 类 号：R994.6[医药卫生—毒理学]