泄浊除痹方治疗高尿酸血症疗效及安全性评价  

Assessment on the Clinical Efficacy and Safety of Xiezhuo Chubi Recipe in Treating Hyperuricemia

作　　者：张娴娴[1] 孙维峰[1] 徐伟[1] 王天[1] 

机构地区：[1]广州军区广州总医院中医科,广州510010

出　　处：《中国中西医结合杂志》2011年第9期1216-1219,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：全军"十一五"计划专项基金项目(No.2006062004);广东省科技计划项目(No.2009B030801277);广州市科技计划项目(No.2010GN-E00221)

摘　　要：目的观察泄浊除痹方对高尿酸血症患者的临床疗效及安全性。方法 99例高尿酸血症患者随机分成泄浊除痹方组、苯溴马隆组、空白对照组。泄浊除痹方组口服泄浊除痹方颗粒剂(每日1剂,分2次服用);苯溴马隆组口服苯溴马隆片(每片50mg,1次/日);空白对照组不用药物治疗,仅进行临床观察,20天为1个疗程。治疗前后观察患者血尿酸,血、尿常规,肝、肾功能等实验室指标的变化并进行统计学分析。结果泄浊除痹方组、苯溴马隆组和空白对照组患者治疗后血尿酸均较前有所下降(P<0.05),治疗总有效率分别为85.71%、92.86%、23.33%;泄浊除痹方组和苯溴马隆组疗效相当,差异无统计学意义(P>0.0167);泄浊除痹方组患者治疗前后血、尿常规,肝、肾功能等安全性指标比较,差异无统计学意义(P>0.05)。结论泄浊除痹方可有效降低高尿酸血症患者血尿酸水平且安全性高。Objective To observe the clinical efficacy and safety of Xiezhuo Chubi Recipe（XCR） on hyperuricemic patients.Methods 99 patients with hyperuricemia were randomly assigned to the XCR group,the Benzbromarone group,and the blank control group.Patients in the XCR group took XCR,one dosage daily,twice per day.Patients in the Benzbromarone group took Benzbromarone Tablet（50 mg each tablet,once per day）.Patients in the blank control group were not treated with any drug,but only with clinical observation.Twenty days consisted of one course of treatment.The laboratory data including uric acid,blood routines,urine routines,the liver function,and the renal function were statistically analyzed before and after treatment.ResultsThe blood uric acid decreased in the three groups after treatment（P0.05）.The total effective rate was 85.71% in the XCR group,92.86% in the Benzbromarone group,and 23.33% in the blank control group.There was no statistical difference between the XCR group and the Benzbromarone group（P0.0167）.There was no significant difference in the safety indices such as blood routines,urine routines,liver functions,and renal functions of the XCR group between before and after treatment（P0.05）.Conclusion XCR could effectively reduce the uric acid level with higher safety.

关 键 词：高尿酸血症 泄浊除痹方 临床疗效与安全性 

分 类 号：R259[医药卫生—中西医结合]