丁香酸衍生物的合成及抗血小板聚集活性  

Synthesis and anti-platelet aggregation activity of syringic acid derivatives

作　　者：袁明[1] 赵永海[1] 李家明[1] 周鹏[1] 盛日正[1] 

机构地区：[1]安徽中医学院药学院安徽省现代中药重点实验室,合肥230031

出　　处：《中国新药杂志》2011年第18期1801-1804,共4页Chinese Journal of New Drugs

基　　金：国家"重大新药创制"科技重大专项(2009ZX09103-123);安徽省自然科学基金项目(070413118)

摘　　要：目的:合成丁香酸衍生物并考察其抗血小板聚集活性。方法:以丁香酸乙酯为原料,经W il-liamson醚化和水解反应合成丁香酸衍生物,并通过抗血小板聚集试验对目标化合物进行抗血小板聚集活性评价。结果与结论:合成了2个目标化合物,其结构经IR,1H-NMR,13C-NMR及MS确证。初步药理实验结果表明,目标化合物在体外显示出较好的抗血小板聚集活性。Objective： To synthesize syringic acid derivatives and evaluate their anti-platelet aggregation activity. Methods： Syringic acid derivatives were synthesized from ethyl syringate via Williamson etherifation and hydroxylation. The target compounds were assayed for anti-platelet aggregation activity in vitro. Results and conclusion： Two compounds were synthesized. Their structures were confirmed by IR, ^1H-NMR, 13C-NMR and MS. Preliminary pharmacological results showed that the tested compounds exhibited potential anti-platelet aggregation activity.

关 键 词：丁香酸衍生物 益母草碱 抗血小板聚集活性 合成 

分 类 号：R973.2[医药卫生—药品]