复方野菊花抗感软胶囊清热解毒作用的实验研究  

Experiment Research on Heat-clearing and Detoxification activities of Compound Chrysanthemum indicum Soft Capsule

作　　者：苏冀彦[1] 谭丽容[1] 赖平[2] 叶木荣[2] 张奉学[3] 陈建南[1] 苏子仁[1] 

机构地区：[1]东莞广州中医药大学中医药数理工程研究院,广东东莞523808 [2]广州中医药大学中药学院,广州510006 [3]广州中医药大学热带医学研究所,广州510405

出　　处：《中药新药与临床药理》2011年第5期479-484,共6页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：国家自然科学基金(U0732004);国家科技重大专项(2009ZX09103-376)

摘　　要：目的观察复方野菊花抗感软胶囊的清热解毒作用。方法以体内外抗流感病毒实验,体内外抗菌、解热实验,评价复方野菊花抗感软胶囊的清热解毒作用。结果复方野菊花抗感软胶囊可明显抑制甲型H1N1流感病毒导致的肺部病变,降低其死亡率(P<0.05),但在最大无毒浓度下(1.56μg/mL)对甲型H1N1流感病毒无血凝抑制作用;明显降低感染金黄色葡萄球菌、乙型溶血性链球菌小鼠的死亡率(P<0.05),对乙型溶血性链球菌和肺炎链球菌的最小抑菌浓度为2.5 mg/mL;可明显缓解干酵母致热大鼠和大肠杆菌内毒素致热家兔的体温升高。结论复方野菊花抗感软胶囊可通过抗流感病毒、抗菌、解热等药理作用发挥其清热解毒功效。Objective To investigate the heat-clearing and detoxification activities of Compound Chrysanthemum indicum Soft Capsule （CISC）. Methods The heat-clearing and detoxification effect of CISC was observed by in vivo and in vitro anti-influenza virus and anti-bacterial experiments, and by the fever-relieving experiments. Results CISC could significantly inhibit the pulmonary pathological changes and decrease the death rate caused by influenza A virus H1NI（P 〈 0.05）. However, CISC had no suppression on hemagglutination caused by influenza A virus H1N1 at the maximum non-toxicity concentration of 1.56 μg/mL. CISC exhibited remarkable anti-bacterial activity by decreas ing the death rate of rats with staphylococcus aureus infection and hemolytic streptococcus-β infection（P 〈 0.05）, and the minimal inhibitory concentration on hemolytic streptococcus-β and streptococcus pneumoniae was 2.5 mg/mL. Moreover, CISC could also relieve the fever caused by dried yeast in rats and by endotoxin in rabbits. Conclusion CISC is proved to possess the heat-clearing and detoxify activities through the anti-influenza virus, anti-bacterial and fever-relieving pharmacological actions.

关 键 词：复方野菊花抗感软胶囊 抗流感病毒 抗菌 解热 

分 类 号：R285.5[医药卫生—中药学]