三七总皂苷对急性心梗后左室重构大鼠心功能的改善作用  

Study of Panax Notoginsenoside in Improving Cardiac Function in Rats with Left Ventricular Remodeling After Acute Myocardial Infarction

作　　者：陈剑梅[1] 郭洁文[1] 李丽明[1] 邱光清[2] 符永恒[3] 邓志军[1] 

机构地区：[1]广州市中医医院,广州510130 [2]广东省药物研究所,广州510440 [3]广东省人民医院医学研究中心广东省心血管病研究所,广州510080

出　　处：《中药新药与临床药理》2011年第5期514-517,共4页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：广东省社会发展领域科技计划项目(83100);广东省中医药局基金项目(2008005;2010274);广州市中医药中西医结合科研项目(20112A011011)

摘　　要：目的研究三七总皂苷(PNS)对急性心肌梗塞(AMI)后左室重构(LVRM)大鼠心功能的作用,并与比索洛尔的疗效作比较。方法除假手术组外采用结扎大鼠左冠状动脉前降支的方法建立AMI模型,术后24h后随机分为正常对照组和实验组,连续4周分别灌胃给予生理盐水2 mg.kg-1、比索洛尔25 mg.kg-1和PNS40、80、120 mg.kg-1,观察PNS和比索洛尔对病鼠室间隔舒张末期厚度(IVSd)、左室舒张末期内径(宽度)(LVIDd)、室间隔收缩末期厚度(IVSs)、左室收缩末期内径(宽度)(LVIDs)、左室后壁舒张末期厚度(LVPWd)、左室后壁收缩末期厚度(LVPWs)、左室射血分数(EF)、左室收缩百分率(FS)、二尖瓣口舒张早期血流速度(MV)、心率(HR)等反映心功能变化指标的影响。结果 PNS高、中剂量组与比索洛尔组的MV、EF均明显上升(P<0.01),中剂量PNS组及比索洛尔组的FS明显上升、LVIDd和LVIDs则减小(P<0.01～0.05)。结论 PNS及比索洛尔均具有改善AMI后LVRM病鼠心功能的作用,可用于治疗心梗后的左室重构。Objective To compare the effect of panax notoginsenoside （PNS） and bisoprolol on improving the cardiac function in rats with left ventricular remodeling（LVRM） after acute myocardial infarction（AMI）. Methods Models of AMI were established by ligation of left anterior descending coronary artery in all of the rats except for the sham-operation group. Twenty-four hours after ligation, AMI rats were given gastric gavage of normal saline （2 mg kg-1, model group）, bisoprolol（25 mg kg-1, bisoprolol group） and PNS（40, 80 and 120 mg kg-1, PNS groups） respectively for 4 consecutive weeks. After treatment, we observed the rats cardiac function index such as end-diastolic intraventrieular septal thickness （ IVSs ）, left ventricular end-diastolic dimension （LVIDd） , end-systolic intraventricular septal thickness （ IVSs ）, left ventricular end -systolic diameter （LVIDs）, end-diastolic left ventricular posterior wall thickness （LVPWd）, end-systolic left ventricular posterior wall thickness （LVPWs）, ejection fraction （EF）, the percentage of left ventricular systolic（FS）, early-diastolic mitral orifice flow velocity （MV） , and heart rate（HR）. Resuits Compared with the model group, EF and MV were significantly improved in high- and middle-dose PNS groups and bisoprolol group（P 〈 0.01） , and FS was increased while LVIDd and LVIDs were decreased in middledose PNS group and bisoprolol group（P 〈 0.01-0.05）. Conclusion Both PNS and bisoprolol can improve the cardiac function in LVRM rats after AMI, and they can be used to treat LVRM rats after AMI.

关 键 词：三七总皂苷 比索洛尔 心肌梗塞 左室重构 心功能 大鼠 

分 类 号：R285.5[医药卫生—中药学]