洛汀新与缬沙坦对AMI患者心功能影响的临床对比观察  

Clinical comparative study of lotensin and valsartan on cardiac function in patients with AMI

作　　者：姚诚 

机构地区：[1]新疆维吾尔自治区克州人民医院,新疆克州845350

出　　处：《中国当代医药》2011年第25期55-56,共2页China Modern Medicine

摘　　要：目的:探讨洛汀新与缬沙坦对抑制急性心肌梗死(AMI)患者左室重塑的疗效及对心功能的影响。方法:将符合WHO规定的AMI诊断标准的51例患者分为两组,其中缬沙坦组27例、洛汀新组24例,两组均行AMI常规治疗,缬沙坦组加用缬沙坦80mg/d、洛汀新组加用洛汀新10mg/d,疗程3个月。结果:两组患者的症状评分与治疗前比较,差异有统计学意义(P<0.05)。两组患者的LVESV、LVEF和LVMI较治疗前均明显改善,差异有统计学意义(P<0.05);而且洛汀新组改善情况优于缬沙坦组(P<0.05)。结论:洛汀新和缬沙坦均能明显改善左室功能,阻抑左室重塑过程,提高左室收缩的同步性,而洛汀新的效果优于缬沙坦。Objective：To investigate the inhibitory effect of valsartan and lotensin on the acute myocardial infarction（AMI） in patients with left ventricular remodeling and its effect on cardiac function.Methods：51 AMI patients were divided into valsartan group 27 cases and lotensin group 24 cases,two groups of AMI underwent conventional treatment,valsartan group added valsartan 80 mg/d,lotensin group added lotensin 10 mg/d,the treatment couse was 3 months.Results：There was significant difference of symptom score between the two groups compared with those before treatment（P〈0.05）.The two groups of patients with LVESV,LVEF and LVMI were significantly improved compared with before treatment,there was significant difference（P〈0.05）;and the improvement of lotensin group was better than the valsartan group（P〈0.05）.Conclusion：Lotensin and valsartan can significantly improve the left ventricular function,inhibit the left ventricular remodeling and improve left ventricular systolic synchrony;and the effect of lotensin is superior to valsartan.

关 键 词：洛汀新 缬沙坦 急性心肌梗死 左室重塑 

分 类 号：R972[医药卫生—药品]