双波长法测定凝胶剂中甲磺酸帕珠沙星的含量  

Content determination of mesilate pazufloxacin in gel by double-wavelength spectrophotometry

作　　者：张坤水[1] 陈逸生[2] 余楚钦[3] 陈剑勇[3] 

机构地区：[1]中山大学孙逸仙纪念医院药学部,广东广州510120 [2]中山大学附属第五医院临床药学部,广东珠海519000 [3]广东药学院药物研究所,广东广州510006

出　　处：《中国当代医药》2011年第26期50-51,共2页China Modern Medicine

摘　　要：目的:建立甲磺酸帕珠沙星凝胶中甲磺酸帕珠沙星含量的测定方法。方法:采用双波长紫外分光光度法,测定波长为247nm,参比波长为232nm,测得吸收度差值(ΔA)为定量依据。结果:甲磺酸帕珠沙星在3～10μg/ml浓度范围内线性良好,相关系数为0.9993,平均加样回收率为100.3%,RSD为1.4%(n=9)。结论:本方法测定甲磺酸帕珠沙星凝胶的含量,可消除辅料的干扰,其方法简便、快速、准确。Objective：To set up a quantitative double-wavelength spectrophotometry method for the content determination of mesilate pazufloxacin in gel products.Methods：The double-wavelength,247 nm and 232 nm,spectrophotometry was used for determining the content of the mesilate pazufloxacin gel.Results：The linear ranges of Mesilate pazufloxacin was 3-10 μg/ml,r=0.999 3.The average recoveries was 100.3%,RSD=1.4%.Conclusion：The method can eliminate interference of excipient,and it is simple and accurate.

关 键 词：甲磺酸帕珠沙星 凝胶剂 双波长法 含量测定 

分 类 号：R927.2[医药卫生—药学]