基于Isthmin和RGD基序的复合物对胶质瘤U251的治疗作用  

Complex based on Isthmin and RGD motif against glioma U251 cells

作　　者：陈宏颉[1] 曹磊[1] 王守森[1] 郑兆聪[1] 王如密[1] 汪君[2] 

机构地区：[1]南京军区福州总医院神经外科,福州350025 [2]广州军区广州总医院

出　　处：《中华实验外科杂志》2011年第10期1737-1739,共3页Chinese Journal of Experimental Surgery

摘　　要：目的探讨基于Isthmin和RGD基序的复合物对胶质瘤U251的治疗效应。方法构建Isthmin和RGD基序的复合物，并建立胶质瘤U251移植瘤模型，体内外观察其对U251细胞和血管内皮细胞的影响。结果该复合物能有效诱导U251细胞的凋亡，抑制肿瘤血管的生成，从而抑制肿瘤的生长和延长荷瘤小鼠的平均生存率。结论该复合物能同时靶向肿瘤和血管内皮细胞，为胶质瘤的基因治疗提供了较理想的策略。Objective To study the effect of complex based on Isthmin arid RGD motif against glioma U251 cells. Methods The complex based on Isthmin and RGD motif was prepared, and the glioma U251 cell xenografts were established to observe the antitumor and antiangiogenesis effects of the complex in vivo and in vivo. Results The complex could induce U251 cell apoptosis and attack tumor endothelium cells, which inhibited the growth of glioma U251 cells and improved the lifespan of tumor bearing mice. Conclusion The complex based on Isthmin and RGD motif could dually target tumor and endothelium cells, which provided a promising strategy for glioma gene therapy.

关 键 词：Isthmin 胶质瘤 基因治疗 

分 类 号：R563.9[医药卫生—呼吸系统]