雌激素代谢酶CYP17、CYP1A2基因多态性与子宫肌瘤易感性的关系  

Relationship between gene polymorphisms of estrogen metabolic enzymes-CYP17 and CYP1A2 and the susceptibility of hysteromyoma

作　　者：王晓莉[1] 曾静[1] 王璟[1] 陈君辉[1] 胡婷[1] 熊万春[1] 

机构地区：[1]四川省成都市第二人民医院,610017

出　　处：《中国妇幼保健》2011年第27期4201-4203,共3页Maternal and Child Health Care of China

基　　金：四川省卫生厅科研基金资助项目〔070375〕

摘　　要：目的:探讨参与雌激素合成和代谢的CYP17和CYP1A2基因多态性与成都地区子宫肌瘤发病的关系。方法:应用聚合酶链反应—限制性片段长度多态性(PCR-RFLP)技术,对100例子宫肌瘤患者和100例对照组人群CYP17基因启动子区T-C多态和CYP1A2基因2964位点G-A多态性进行分析。结果:两组均存在CYP17基因T-C多态,但两组基因型TT、TC、CC频率和等位基因T、C频率的比较差异均无统计学意义(P>0.05);两组均存在CYP1A2基因G-A多态,但两组基因型GG、GA、AA频率和等位基因G、A频率的比较差异均无统计学意义(P>0.05)。结论:CYP17基因启动子区T-C多态和CYP1A2基因2964位点G-A多态性与成都地区子宫肌瘤发病风险无相关性。Objective：To explore the relationship between gene polymorphisms of CYP17 and CYP1A2 who participate in the synthesis and metabolism of estrogen and the occurrence of hysteromyoma in Chengdu. Methods：PCR-RFLP was used to analyze T-C polymorphism in CYP17 gene promoter region and G-A polymorphism in 2964 locus of CYP1A2 gene in 100 patients with hysteromyoma and 100 cases in control group. Results：T-C polymorphism of CYP17 gene existed in the two groups,but there was no significant difference in the frequencies of TT genotype,TC genotype and CC genotype,T allele and C allele between the two groups（P0.05）;G-A polymorphism of CYP1A2 gene existed in the two groups,but there was no significant difference in the frequencies of GG genotype,GA genotype and AA genotype,G allele and A allele（P0.05）. Conclusion：There is no correlation between T-C polymorphism in CYP17 gene promoter region,G-A polymorphism in 2964 locus of CYP1A2 gene and the risk of occurrence of hysteromyoma in Chengdu.

关 键 词：子宫肌瘤 CYP17基因 CYP1A2基因 遗传多态性 

分 类 号：R711.74[医药卫生—妇产科学]