法莫替丁或奥美拉唑联合立止血治疗新生儿消化道出血的疗效观察  

Observation on the curative effects of famotidine or omeprazole combined with reptilase in treatment of neonatal gastrointestinal hemorrhage

作　　者：宋晓美[1] 

机构地区：[1]济宁医学院附属金乡人民医院儿科,山东金乡272200

出　　处：《中国妇幼保健》2011年第27期4276-4277,共2页Maternal and Child Health Care of China

摘　　要：目的:探讨法莫替丁、奥美拉唑分别与立止血联合治疗新生儿消化道出血的临床疗效。方法:选择该院自2010年2月～2010年11月收治的90例消化道出血的新生儿患者,随机分为3组,奥美拉唑联合立止血组(治疗A组)32例,法莫替丁联合立止血组(治疗B组)31例,西咪替丁(对照组)27例。治疗A组静脉滴注奥美拉唑针0.9 mg/kg,同时给予立止血0.5 kU静脉注射,每日1次;治疗B组给予法莫替丁针0.9 mg/kg,同时静脉注射0.5 kU,每日1次,对照组给予西咪替丁10 mg/kg,每日1次,疗程为3天。1个疗程后观察疗效。结果:治疗后A组、B组、对照组的总有效率分别为93.75%(30/32)、93.55%(29/31)、77.78%(21/27)。治疗A组与治疗B组总有效率比较无统计学差异(P>0.05),两组分别与对照组比较,差异具有统计学意义(P<0.05)。奥美拉唑、法莫替丁联合立止血与西咪替丁分别治疗新生儿消化道出血,疗程结束后未出现不良反应。结论:奥美拉唑、法莫替丁分别联合立止血治疗新生儿消化道出血两种方法比较无统计学差异,是临床上有效的、安全的治疗方法。Objective：To explore the clinical curative effects of famotidine combined with reptilase and omeprazole combined with reptilase in treatment of neonatal gastrointestinal hemorrhage. Methods：90 neonates with gastrointestinal hemorrhage who were treated in the hospital from February 2010 to November 2010 were selected and divided into three groups randomly： treatment A group（including 32 neonates treated with omeprazole combined with reptilase）,treatment B group（including 31 neonates treated with famotidine combined with reptilase） and control group（including 27 neonates treated with cimetidine）.The neonates in treatment A group were treated with intravenous drip of omeprazole（0.9mg/kg） and intravenous injection of reptilase（0.5kU）,once a day;the neonates in treatment B group were treated with intravenous drip of famotidine（0.9mg/kg） and intravenous injection of famotidine（0.5kU）,once a day;the neonates in control group were treated with cimetidine,10 mg/kg,once a day,three days for a course of treatment.The curative effects in the three groups were observed after one course. Results：After treatment,the total effective rates in treatment A group,treatment B group and control group were 93.75%（30/32）,93.55%（29/31） and 77.78%（21/27）,respectively.There was no significant difference in total effective rate between treatment A group and treatment B group（P0.05）,but there was significant difference in total effective rate between treatment A group,treatment B group and control group,respectively（P0.05）.No adverse reactions occurred. Conclusion：There is no significant difference in curative effect between famotidine combined with reptilase and omeprazole combined with reptilase in treatment of neonatal gastrointestinal hemorrhage,the two methods are both effective and safe therapies in clinic.

关 键 词：新生儿 奥美拉唑 法莫替丁 立止血 西咪替丁 消化道出血 

分 类 号：R722.152[医药卫生—儿科]