苦参碱及其衍生物合成及生物活性研究进展  

Advances in Synthesis and Biological Activity of Matrine and Its Derivatives

作　　者：何雄[1] 韦星船[1] 田裕昌[1] 赖家雄[1] 

机构地区：[1]广州大学化学化工学院,广州510006

出　　处：《中国现代应用药学》2011年第9期816-823,共8页Chinese Journal of Modern Applied Pharmacy

摘　　要：目的综述苦参碱及其衍生物的最新研究进展。方法通过查阅大量相关文献,对苦参碱及其衍生物的合成和药理活性资料进行整理、分析,并总结了一部分化合物的构效关系。结果与结论大多数苦参碱衍生物在抗肿瘤、抑菌、抗炎镇痛等方面的生物活性都有较大的提高。OBJECTIVE To introduce advances in research of matrine and its derivates.METHODS Based on the correlative materials from documents,the synthesis and pharmacology of matrine and its derivates had been briefly summarized.The structure-activity relationship of some matrine derivates was included.RESULTS CONCLUSION Many bioactivities of matrine derivates have been improved greatly,such as antitumor,antisepsis,anti-inflammation and analgesicis.

关 键 词：苦参碱 苦参碱衍生物 合成 生物活性 药理活性 

分 类 号：R285[医药卫生—中药学]