缺氧缺血性脑损伤  

Hypoxic-Ischemic Brain Damage in Children

作　　者：邹峥[1] 刘小惠[1] 邹大卫[1] 

机构地区：[1]江西省儿童医院风湿免疫科,南昌330006

出　　处：《实用儿科临床杂志》2011年第18期1446-1449,共4页Journal of Applied Clinical Pediatrics

基　　金：国家"十一.五"科技支撑项目(2008BAI68B07)

摘　　要：由于高代谢的需要,脑高度的依赖充分的氧供给,全脑性缺氧/缺血会导致快速的能量丧失,引起一连串的包括兴奋毒性损伤、炎症和凋亡所共同造成的脑损伤。围生期窒息复杂的先天性心脏病开放性手术及意外的捂热综合征均是酿成缺氧/缺血脑损伤的危险因素。缺氧/缺血愈久,损伤愈重,预后也愈差。因而需及早给予积极和恰当的治疗。Due to its high metabolism demand,the brain is highly dependent on sufficient oxygen supply so that hypoxia-ischemia of the global brain results in a rapid depletion of energy stores that trigger a complex and cascade of celluar events including excitotoxic injury,inflammation and apoptosis of the brain tissue.Perinatal asphyxia complex congenital open heart surgery and muggy disease are risk factors to induce hypoxia-ischemia brain damage.Severity and duration determine the ultimate prognosis,so that the hypoxia-ischemia patients should be early,actively and properly treated.

关 键 词：缺氧缺血 脑损伤 儿童 

分 类 号：R722.1[医药卫生—儿科]