Comparison on Photopic Electroretinogram Negative Response between Young and Old Lewis Rats  

作　　者：Yiqun Geng Hongling Chen Lifang Liu Hongjie Lin Mingzhi Zhang 

机构地区：[1]Central Laboratory of Shantou University, Chinese Universtiy of Hong Kong Joint Shantou International Eye Center, Shantou 515041, China

出　　处：《Eye Science》2011年第3期171-172,共2页眼科学报（英文版）

基　　金：Development Program for Innovative Young Talents in Colleges and Universities in Guangdong Province(grant No.LYM08057);Internal Project of Joint Shantou International Eye Center of Shantou University and The Chinese University of Hong Kong(07-11)

摘　　要：Purpose:To investigate and compare the latency and amplitude of the electroretinogram(ERG) photopic negative response(PhNR) between young and old Lewis rats.Methods:Thirteen Lewis rats were divided into two groups according to ages,young group(3-month old,n=5) and old group(24 month old,n=8).The ERGs of the left eyes were measured and the latency and amplitude of a-wave,b-wave and PhNRs were recorded and compared according to ages.The mean values between two groups were statistically analysed by t-test.Results:The latency of PhNRs was evidently prolonged in old group and showed significant difference(P<0.05).There was no statistically significant difference between two groups regarding the amplitude and latency,and no significant difference was noted in the amplitude of PhNRs.Conclusion:The prolonged latency of PhNR in aged rats possibly associate with the influence of aging upon retinal ganglion cell layer(RGCL).Purpose： To investigate and compare the latency and amplitude of the electroretinogram （ERG） photopic negative response （PhNR） between young and old Lewis rats. Methods： Thirteen Lewis rats were divided into two groups according to ages, young group （3-month old, n=5） and old group （24 month old, n=8）. The ERGs of the left eyes were measured and the latency and amplitude of a-wave, b-wave and PhNRs were recorded and compared according to ages. The mean values between two groups were statistically analysed by t-test. Results： The latency of PhNRs was evidently prolonged in old group and showed significant difference（P〈0.05）. There was no statistically significant difference between two groups regarding the amplitude and latency, and no significant difference was noted in the amplitude of PhNRs. Conclusion ： The prolonged latency of PhNR in aged rats possibly associate with the influence of aging upon retinal gan- glion cell layer （ RGCL ）. （ Eye Science 2011 ; 26：171-172 ）

关 键 词：老年人 年轻人 大鼠 反应 统计学分析 视网膜电图 潜伏期 幅度 

分 类 号：Q959.837[生物学—动物学] TQ028.8[化学工程]