Rs548234 polymorphism at PRDM1-ATG5 region susceptible to rheumatoid arthritis in Caucasians is not associated with rheumatoid arthritis in Chinese Han population  

作　　者：LU Xiao-lan ZHOU Xu-jie GUO Jian-ping JIA Ru-lin ZHAO Yi JIANG Quan LIU Xiang-yuan LIU Yi SUN Ling-yun ZHANG Hong LI Zhan-guo 

机构地区：[1]Department of Rheumatology and Immunology, Peking University People's Hospital, Beijing 100044, China [2]Renal Division, Peking University First Hospital, Peking University Institute of Nephrology, Key Laboratory of Renal Disease, Ministry of Health of China, Beijing 100034, China [3]Department of Rheumatology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China [4]Department of Rheumatology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China [5]Department of Rheumatology and Immunology, Peking University Third Hospital, Beijing 100191, China [6]Department of Rheumatology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China [7]Department of Rheumatology, Drum Tower Hospital, Nanjing University Medical School, Nanjing, Jiangsu 210008, China

出　　处：《Chinese Medical Journal》2011年第18期2863-2867,共5页中华医学杂志（英文版）

基　　金：This work was supported by grants from the Major State Basic Research Development Program of China （973 Program） （No. 2010CB529100） and Key Program of the National Natural Science Foundation of China （No. 81030057）.

摘　　要：Background A previous study has shown that rs548234 polymorphism at PRDM1-ATG5 region is associated with rheumatoid arthritis （RA） in Caucasian populations. The aim of this study was to investigate the effect of rs548234 polymorphism at PRDM1-ATG5 region on susceptibility to RA in Chinese Han population. Methods We genotyped 848 RA patients and 1431 matched healthy controls for rs548234 single-nucleotide polymorphism （SNP） with a predesigned TaqMan SNP genotyping assay. Association analyses were performed on the whole data set and on rheumatoid factors （RF） and anti-cyclic citrullinated peptides （anti-CCP） antibody. Finally, we carried out combined analysis of rs548234 association with RA based on the published data. Results No significant difference in the genotype distribution between RA patients and healthy controls for rs548234 （C/T） polymorphism was found in Chinese Han population, neither in whole data set nor in stratified subsets, e.g. RF and anti-CCP status. Association analysis in different ethnic groups showed that rs548234 at PRDM1-ATG5 region was associated with RA in Caucasian ancestry but not in East Asian population. Conclusions Our results showed no involvement of rs548234 at PRDM1-ATG5 region in the susceptibility or clinical relevance of RA in Chinese Han population.Background A previous study has shown that rs548234 polymorphism at PRDM1-ATG5 region is associated with rheumatoid arthritis （RA） in Caucasian populations. The aim of this study was to investigate the effect of rs548234 polymorphism at PRDM1-ATG5 region on susceptibility to RA in Chinese Han population. Methods We genotyped 848 RA patients and 1431 matched healthy controls for rs548234 single-nucleotide polymorphism （SNP） with a predesigned TaqMan SNP genotyping assay. Association analyses were performed on the whole data set and on rheumatoid factors （RF） and anti-cyclic citrullinated peptides （anti-CCP） antibody. Finally, we carried out combined analysis of rs548234 association with RA based on the published data. Results No significant difference in the genotype distribution between RA patients and healthy controls for rs548234 （C/T） polymorphism was found in Chinese Han population, neither in whole data set nor in stratified subsets, e.g. RF and anti-CCP status. Association analysis in different ethnic groups showed that rs548234 at PRDM1-ATG5 region was associated with RA in Caucasian ancestry but not in East Asian population. Conclusions Our results showed no involvement of rs548234 at PRDM1-ATG5 region in the susceptibility or clinical relevance of RA in Chinese Han population.

关 键 词：rheumatoid arthritis PRDM1/ATG5 genetic association Chinese Han population 

分 类 号：Q987[生物学—遗传学] Q347[生物学—人类学]