原发性宫颈恶性淋巴瘤8例临床分析并文献复习  

Primary cervical lymphoma:clinical analysis of 8 cases with literature review

作　　者：孙甜甜[1] 王华庆[1] 邱立华[1] 张会来[1] 钱正子[1] 付凯[1] 郝希山[1] 

机构地区：[1]天津医科大学附属肿瘤医院淋巴瘤科天津市肿瘤防治重点实验室中美淋巴血液肿瘤诊治中心,天津300060

出　　处：《中国实用妇科与产科杂志》2011年第10期764-766,共3页Chinese Journal of Practical Gynecology and Obstetrics

摘　　要：目的探讨原发性宫颈恶性淋巴瘤(primary cervical lymphoma,PCL)临床特点、治疗方法及预后因素。方法 2000年1月至2009年12月天津医科大学附属肿瘤医院收治8例PCL,总结其年龄、症状、体征、胸片和(或)CT、盆腔B超和(或)CT和(或)MRI、阴道镜、骨髓分类、治疗方法、生存时间等临床资料,并结合国内外文献进行分析。结果 2000年至2009年间天津市平均人口数中PCL的发病率为7.53/1000万。8例患者中位年龄45.5岁,均为非霍奇金淋巴瘤,B细胞型7例,包括弥漫大B细胞淋巴瘤6例;T细胞型1例。年龄≥60岁与<60岁平均生存12.3个月和48.4个月;肿瘤直径≥3.5cm与<3.5cm者平均生存28.0个月和46.3个月;小淋巴细胞淋巴瘤、外周T细胞淋巴瘤和弥漫大B细胞淋巴瘤平均生存87、54和23个月;乳酸脱氢酶(LDH)升高与正常者平均生存15.0、37.7个月;β2微球蛋白(β2-MG)升高与正常者平均生存15.0、37.7个月;手术+化疗、化疗+放疗、单纯化疗的平均生存期分别为38.3、40.0和28.7个月。结论 PCL临床罕见,临床表现不典型,病理类型主要为弥漫大B细胞淋巴瘤,年龄、肿瘤大小、病理类型、LDH、β2-MG、治疗方式等因素可能与预后相关。Objective To explore the clinical feature, therapy and prognostic factors of primary cervical lymphoma （PCL）. Methods From Jan. 2000 to Dec. 2009, 8 cases with PCL in Tianjin Medical University Affiliated Cancer Hospital were treated. The clinical data of these 8 cases, including age, symptom, sign, the examination of chest X-rays and （or） CT, B ultrasound and （or） CT and （or） MRI of pelvic cavity, vagina endoscope, marrow classify, therapy and survival were retrospectively analyzed and the related references were reviewed. Results From 2000 to 2009, the inci- dence of PCL was 7.53/10 millions in Tianjin. Their median age was 45.5 years. They veere all non-lAodgking lympho- ma. 7 were B-cell NHL, including 6 diffuse large B-cell lymphoma; 1 was T-cell NHL. Mean survival of different ages （ t〉60, 〈60） were 12.3 and 48.4 months, respectively. Mean smwival of different tumor size （≥3.5cm, 〈3.5era） were 28.0 months and 46.3 months, respectively. Mean survival of small lymphocytic lymphoma, peripheral T-cell lym- phoma and diffuse large B-cell lymphoma were 87, 54 and 23 months, respectively. Patients with elevated LDH had a mean survival of 15.0 months compared with 37.7 months of those with normal LDH. Mean survial of different [32-MG le- vers （high, normal） were 15.0 months and 37.7 months. Mean survival of surgery plus chemotherapy, chemotherapy plus radiotherapy and chemotherapy alone were 38.3, 40.0 and 28.7 months, respectively. Conclusion PCL is a rare kind of extranodal lymphoma. The clinical manifestation is atypical. The pathology is mainly diffuse large B-cell lympho- ma. Age, tumor size, pathology, LDH, [32-MC and therapy are associated with prognosis.

关 键 词：原发宫颈淋巴瘤 发病率 临床特点 预后 

分 类 号：R714.255[医药卫生—妇产科学]